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FLASH GENE

Symbol

OAT

contributors: mct/npt - updated : 17-06-2009

HGNC name	ornithine aminotransferase
HGNC id	8091

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	OATD hyperornithinemia with ornithine aminotransferase deficiency
Location	10q26.13      Physical location : 126.085.871 - 126.107.545
Synonym name	ornithine aminotransferase precursor
	ornithine--oxo-acid aminotransferase
	gyrate atrophy
Synonym symbol(s)	DKFZp781A11155, HOGA, OATASE, OKT
EC.number	2.6.1.13

DNA

TYPE	functioning gene
STRUCTURE	21.65 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	cen - TSG10A /D10S583 - HOX11 ,PAX2 ,SCA8 SCA8 ,PEO1 - HMX2 ,SLC18A2 - TSG10B - FGFR2 - OAT - qter
Authors	Ehrlich (96)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001171814 - - 1874 NP_001165285 - 301 - - NM_000274 10 - 2102 NP_000265 45.14 439 - Mashima (1992)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       highly Digestive esophagus       predominantly   pharynx       highly Nervous brain         Reproductive female system breast         female system uterus       Respiratory respiratory tract trachea     highly Skin/Tegument skin         Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Connective bone

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , tetramer

HOMOLOGY

interspecies	ortholog to rattus Oat
	ortholog to murine Oat

Homologene

FAMILY

class-III pyridoxal-phosphate-dependent aminotransferase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix

basic FUNCTION	ornithine aminotransferase, proline and ornithine metabolic pathway
	controls the l-ornithine level in tissues by catalyzing the transfer of the delta-amino group of l-ornithine to 2-oxoglutarate, producing l-glutamate- gamma-semialdehyde and l-glutamate (Storici 1999)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

aminoacid

signaling

sensory transduction/vision

a component

INTERACTION

DNA

RNA

small molecule	cofactor,
	pyridoxal phosphate

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

OATD

related resource

MITOP database Retinal Information Network

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS