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FLASH GENE
Symbol OASL contributors: - updated : 14-09-2005
HGNC name 2'-5'-oligoadenylate synthetase-like
HGNC id 8090
Location 12q24.2      Physical location : 121.458.094 - 121.476.780
Synonym name thyroid hormone receptor interactor 14
Synonym symbol(s) TRIP14, p59OASL
DNA
TYPE functioning gene
STRUCTURE 18.00 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 2155 56 513 - Rebouillat
- - 1820 59 514 - Hartmann
- - 470 30 153 - Lee
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 stomach    
Reproductivemale systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DNA and sRNA binding domains but devoid of catalytic activity
  • two ubiquitin-like domains
  • 350 amino acid N-terminal domain lacks 2'-5' oligoadenylate synthetase activity
  • C-terminal 164 amino acid domain, homologous to a tandem repeat of ubiquitin
  • HOMOLOGY
    interspecies homolog to C.elegans c05c10.3
    Homologene
    FAMILY 2,5-oligodenylate synthetase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION transferase activity
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism hormone
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule nucleotide,
    ATP binding
    protein
  • with the ligand binding domain of thyroid hormone receptor
  • interacting with MBD1
  • binding double- stranded RNA and DNA
  • cell & other
    REGULATION
    induced by interferon induced
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS