Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol OAS2 contributors: npt/mct - updated : 25-09-2010
HGNC name 2'-5'-oligoadenylate synthetase 2, 69/71kDa
HGNC id 8087
Location 12q24.13      Physical location : 113.416.273 - 113.449.527
Synonym name
  • polynucleotide adenylyltransferase
  • p69OAS / p71OAS
  • 2'-5')oligo(A) synthetase 2
  • Synonym symbol(s) MGC78578
    EC.number 2.7.7.-
    DNA
    TYPE functioning gene
    STRUCTURE 33.26 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 3647 69 687 - Marie, Hovnanian (1998)
    also called variant 2 or p69
    11 - 3539 - 719 - Marie, Hovnanian (1998)
    also called variant 1 or p71
    2 - 2123 - 172 - Justesen (2000)
    also called variant 3
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     spleen   highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • 2-5a synthetase family
  • CATEGORY enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,nucleus
    basic FUNCTION
  • may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis
  • dsRNA binding protein involved in the pathway that activates RNASEL (Dugan 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    nucleotide
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • binding partner for NOD2 (Dugan 2009)
  • cell & other
    REGULATION
    induced by interferon induced
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS