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FLASH GENE
Symbol OAS1 contributors: mct - updated : 11-04-2018
HGNC name 2',5'-oligoadenylate synthetase 1, 40/46kDa
HGNC id 8086
Corresponding disease
PAPHG Pulmonary alveolar proteinosis (PAP) with hypogammaglobulinemia
Location 12q24.13      Physical location : 113.344.738 - 113.357.711
Synonym name polynucleotide adenylyltransferase
Synonym symbol(s) E18/E16, OIAS1, IFI4, IFI-4, OIAS
EC.number 2.7.7.19/ 2.7.7.84
DNA
TYPE functioning gene
STRUCTURE 12.97 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure
  • . ELF1 binds an important duplicated GGAA cis-acting element at the OAS1 promoter and in cooperation with RB1 and SP1 recruitment contributes to regulation in response to IFN stimulation
  • MAPPING cloned Y linked N status confirmed
    Map cen - D12S2296 - D12S2347 - D12S2344 - D12S2271 - D12S2345 - D12S1857 - D12S2253 - D12S2264 - D12S861 - D12S1616 - D12S1340 - D12S2300 - OAS1 /D12S1960 /D12S2019 - (D12S2291 - D12S2247 ),OAS3 /D12S2397 - D12S2277 - OAS2 /D12S1895 /D12S1888 - D12S2293 - D12S2292 - D12S2295 - qter
    Authors Renault (97)
    Physical map
    FLJ32356 12q24.13 hypothetical protein FLJ32356 LNK 12q24 hypothetical protein FLJ32356 SCA2 12q24.1 spinocerebellar ataxia 2 (olivopontocerebellar ataxia 2, autosomal dominant, ataxin 2) BRAP 12q24 BRCA1 associated protein MGC5601 12q24.13 hypothetical protein MGC5601 ALDH2 12q24.2 aldehyde dehydrogenase 2 family (mitochondrial) FLJ39616 12q24.13 apoptosis-related protein PNAS-1 MAPKAPK5 12q24.12 mitogen-activated protein kinase-activated protein kinase 5 ADAM1 12q24.13 a disintegrin and metalloproteinase domain 1 (fertilin alpha) pseudogene LOC89894 12q24.13 hypothetical protein BC000282 C12orf8 12q24.13 chromosome 12 open reading frame 8 FLJ13089 12q24.13 hypothetical protein FLJ13089 FLN29 12q FLN29 gene product FLJ30092 12q24.13 AF-1 specific protein phosphatase FLJ34154 12q24.13 hypothetical protein FLJ34154 RPL6 12q23-q24.1 ribosomal protein L6 PTPN11 12q24.1 protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) RPH3A 12q24.11 protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) OAS1 12q24.2 2',5'-oligoadenylate synthetase 1, 40/46kDa OAS3 12q24.1 2'-5'-oligoadenylate synthetase 3, 100kDa OAS2 12q24.2 2'-5'-oligoadenylate synthetase 2, 69/71kDa DTX1 12q24.1 deltex homolog 1 (Drosophila) RASAL1 12q23-q24 RAS protein activator like 1 (GAP1 like) LOC387885 12 LOC387885 DDX54 12q24.21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 FLJ14827 12q24.21 hypothetical protein FLJ14827 LOC115811 12q24.21 hypothetical protein BC013151 TPCN1 12q24.21 two pore segment channel 1 FLJ22233 LOC196463 12q24.21 hypothetical protein LOC196463 SDS 12q24.1 serine dehydratase SDS-RS1 12q24.21 serine dehydratase related sequence 1 LHX5 12q24.31-q24.32 LIM homeobox protein 5 KIAA0682 12q23.3-q24.2 LIM homeobox protein 5
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1850 46 400 mitochondrial localization 2011 14559211
    8 exons very hydrophilic
    7 - 1650 41 364 - 2011 14559211
    7 exons hydrophobic C terminus
    6 - 1575 48 414 - 2011 14559211
    OAS1 I3
    - - - 44 382 - 2011 14559211
    6 - 1673 46 400 mitochondrial localization 2011 14559211
    5 - 1470 41 364 - 2011 14559211
    6 - 1614 - 360 - 2011 14559211
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Lymphoid/Immunetonsils   highly
    Reproductivefemale systembreastmammary gland highly
     female systemuteruscervix highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • oligoademylate synthase family
  • 2-5A synthetase family essential for innate immune response against viral infection
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • mediating resistance to virus infection, control of cell growth, differentiation and apoptosis
  • plays a central role in the cellular innate antiviral response
  • is one of the major interferon-inducible proteins and a critical component of the host defense system against viral infection
  • potential role of OAS1 polymorphisms in respiratory infection
  • recognizes double-stranded RNA (dsRNA) using a previously uncharacterized protein/RNA interface that forms via a conformational change induced by binding of dsRNA
  • CELLULAR PROCESS cell life, differentiation
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    nucleotide
    a component components of the innate immune response to viruses
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by interferon induced
    ASSOCIATED DISORDERS
    corresponding disease(s) PAPHG
    Susceptibility
  • host susceptibility to viral infection
  • to multiple sclerosis (MS)
  • to prostate cancer
  • to Sjögren's syndrome (SS)
  • Variant & Polymorphism SNP , other
  • influencing host susceptibility to viral infection
  • association between rs10774671 and MS
  • significant association was observed between the rs2660 genotype (A/G) and prostate cancer
  • is a risk locus for SS and support a potential role for defective viral clearance due to altered IFN response as a genetic pathophysiological basis of this complex autoimmune disease
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS