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FLASH GENE
Symbol NYAP1 contributors: mct - updated : 23-08-2013
HGNC name neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1
HGNC id 22009
Location 7q22.1      Physical location : -
Synonym name
  • hypothetical protein FLJ37538
  • chromosome 7 open reading frame 51
  • Synonym symbol(s) FLJ37538, C7orf51
    DNA
    TYPE functioning gene
    STRUCTURE 10.87 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3594 88 841 - Scherer (2003)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   predominantly Homo sapiensFetal
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiensFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY Neuronal tYrosine-phosphorylated Adaptor for the PI 3-kinase (NYAP) family
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • activate PI3K and concomitantly recruit the downstream effector WAVE complex to the close vicinity of PI3K and regulate neuronal morphogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with the WAVE1 complex which mediates remodelling of the actin cytoskeleton after activation by PI3K-produced PIP(3) and RAC1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS