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FLASH GENE
Symbol NXPH1 contributors: - updated : 04-06-2004
HGNC name neurexophilin 1
HGNC id 20693
Location 7p22      Physical location : 8.473.584 - 8.792.592
Synonym symbol(s) NPH1
DNA
TYPE functioning gene
STRUCTURE 319.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal signal peptide
  • a variable N-terminal domain
  • a highly conserved central N-glycosylation site
  • a short linker region
  • a conserved C-terminal cysteine-rich domain
    • conjugated GlycoP
    isoforms Precursor that may be post-translationally cleaved
    HOMOLOGY
    interspecies homolog to rattus Nxph1
    Homologene
    FAMILY neurexophilin family
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION may function as neuropeptides that may signal via alpha-neurexins (interaction ligand-receptor type)
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein NRXN1 and NRXN3 bind preferentially to mature form of NXPH1
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS