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FLASH GENE
Symbol NXF2 contributors: - updated : 20-04-2006
HGNC name nuclear RNA export factor 2
HGNC id 8072
Location Xq22-q23      Physical location : 101.470.279 - 101.726.732
Synonym name tap-like protein 2
Synonym symbol(s) TAPL2, TAPL-2, FLJ20416, CT39
DNA
TYPE functioning gene
STRUCTURE 80.00 kb     24 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
NOX1 Xq22 NADPH oxidase 1 LOC389877 X similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) LOC347424 Xq22.1 similar to TGF beta-inducible nuclear protein 1 (Hairy cell leukemia protein 1) (HUSSY-29) LOC286453 Xq22.1 similar to dJ341D10.1 (novel protein) LOC392509 X similar to hypothetical protein DKFZp761H079 isoform 1 FLJ12687 Xq22.1 hypothetical protein FLJ12687 FLJ14084 Xq22.1 hypothetical protein FLJ14084 FSHPRH1 Xq22 FSH primary response (LRPR1 homolog, rat) 1 LOC392510 X similar to 14-3-3 protein tau (14-3-3 protein theta) DRP2 Xq22 dystrophin related protein 2 TAF7L Xq22.1 TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa TIMM8A Xq22.1 translocase of inner mitochondrial membrane 8 homolog A (yeast) BTK Xq22.1-q22.2 Bruton agammaglobulinemia tyrosine kinase RPL36A Xq26.3-q27.3 ribosomal protein L36a GLA Xq22.11 galactosidase, alpha HNRPH2 Xq21.3-q22 heterogeneous nuclear ribonucleoprotein H2 (H') LOC389878 X LOC389878 MGC40053 Xq22.1 hypothetical protein MGC40053 LOC158948 Xq22.1 protein kinase C, iota pseudogene ALEX1 Xq21.33-q22.2 protein kinase C, iota pseudogene FLJ20811 Xq21.33-q22.3 hypothetical protein FLJ20811 ALEX3 Xq21.33-q22.2 ALEX3 protein ALEX2 Xq21.33-q22.2 ALEX2 protein GKP6 Xq22-q23 glycerol kinase pseudogene 6 NXF5 Xq22 nuclear RNA export factor 5 KIAA1789 Xq21 KIAA1789 protein my048 Xq22.1-q22.3 my048 protein LOC158931 Xq22.1 similar to hypothetical protein MGC15737 LOC340542 Xq22.1 hypothetical protein LOC340542 NXF2 Xq22-q23 nuclear RNA export factor 2 TMSNB Xq21.33-q22.3 thymosin, beta, identified in neuroblastoma cells LOC139707 Xq22.1 similar to checkpoint suppressor 1 NXF4 Xq22 nuclear RNA export factor 4 FLJ12969 Xq22.1-q22.3 hypothetical protein FLJ12969 GASP Xq22.1 G protein-coupled receptor-associated sorting protein LOC114928 Xq22.1 hypothetical protein BC013576 KIAA1701 Xq23 KIAA1701 protein MTND2P2 Xq22.2 NADH dehydrogenase 2 pseudogene 2 LOC286526 Xq22.2 Ras-like GTPase-like BEX1 Xq21-q23 brain expressed, X-linked 1 NXF3 Xq22-q23 nuclear RNA export factor 3 FLJ10097 Xq22.1-q22.3 hypothetical protein FLJ10097 MGC45400 Xq22.2 hypothetical protein MGC45400 LOC340543 Xq22.2 similar to hypothetical protein MGC15737 DJ79P11.1 Xq22 X-linked protein MGC23947 Xq22.1 hypothetical protein MGC23947 LOC51186 Xq22.2 pp21 homolog NGFRAP1 Xq22.1 nerve growth factor receptor (TNFRSF16) associated protein 1 RAB40A Xq22.1 RAB40A, member RAS oncogene family
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 2884 71.6 626 - Herold
  • differing from variant 2 at the 5' UTR
  • encoded protein is identical for both transcript variants
  • - splicing 2346 71.6 626 - Herold
  • differing from variant 2 at the 5' UTR
  • encoded protein is identical for both transcript variants
  • EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemtestis   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatogonia
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-domain required for interaction with KIF17
  • four leucine-rich repeat,RNP-type RNA6 -binding domain-(RBD)
  • a nuclear transport, factor 2 (NF2) like domain and ubiquitine-associated domain
  • a UBA-like domain
  • a RNA recognition motif (RRM) domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Nxf2
    homolog to zebrafish Dr.6607
    homolog to Drosophila sbr
    homolog to C.elegans nxf-1
    intraspecies homolog to NXF1
    Homologene
    FAMILY family of nuclear RNA export factor genes
    CATEGORY RNA associated , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nuclear envelope
    text associated with the nuclear envelope
    basic FUNCTION
  • involved in mRNA export from the nucleus to the cytoplasm
  • a nucleo-cytoplasmic mRNA transporter, playing additional roles in the cytoplasmic localization of mRNAs through interactions with cytoplasmic motor proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text
  • mRNA-nucleus export
  • protein-nucleus import
  • PATHWAY
    metabolism
    signaling
    a component heterodimerized with NXT1 AND NXT2
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • NXT1
  • NXT2
  • E1B-AP5
  • the REF proteins
  • nucleoporins (Nup62, Nup153 and Nup214)
  • interacting with KIF17
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS