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FLASH GENE
Symbol NXF1 contributors: mct/npt/pgu - updated : 13-04-2017
HGNC name nuclear RNA export factor 1
HGNC id 8071
Location 11q12.3      Physical location : 62.559.597 - 62.572.964
Synonym name
  • nuclear RNA export factor 1 (Mex67, yeast, homolog)
  • tip associating protein
  • Synonym symbol(s) TAP, MEX67, DKFZp667O0311
    DNA
    TYPE functioning gene
    STRUCTURE 13.37 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 4147 - 356 is highly expressed in nuclei and dendrites of hippocampal and neocortical neurons in rodent brain 2016 27708137
  • 356-amino acid short NXF1(sNXF1)
  • 21 - 2346 - 619 - 2016 27708137
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas    
    Lymphoid/Immunespleen   highly
     thymus   highly
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a minimal CTE binding domain with a RNP-type RNA binding domain (RBD) and four leucine-rich repeats
  • a nucleoporin binding domain with a NTF2-like domain
  • an ubiquitin-associated (UBA) domain that helps in coordinating transcription elongation and nuclear export by interacting both with ubiquitin conjugates and specific targets, such as THOC1, a component of the THO complex
  • HOMOLOGY
    Homologene
    FAMILY
  • NXF family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text at both the nucleoplasmic and cytoplasmic faces
    of the nuclear pore complex; shuttles between the nucleus and
    the cytoplasm
    basic FUNCTION
  • involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in
  • the export of mRNA from the nucleus to the cytoplasm
  • NXF1/NXT1 heterodimer enhances nucleoporin binding and induces the formation of a NXF1/NXT1/nucleoporin ternary complex that is likely to be a key intermediate in the process of nuclear mRNA export
  • nuclear export of mRNAs is mediated by the NXF1/NXT1 pathway
  • NXF1 is a major nuclear export receptor for the transport of mRNA, and it also is essential for export of retroviral mRNAs with retained introns
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with NXT1
  • part of NXF1 export pathway
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NXT1 is a novel member of the NTF2-like family and interacts with NXF1, forming a complex with a similar structural architecture to that of NXF1/NXT1
  • interaction with THOC1 is required for NXF1-UBA domain to bind polyubiquitin, possibly by inducing an H4-dependent conformational change
  • interaction of RBM15B and RBM15 with NXF1 via their C-terminal regions
  • association with THRAP3
  • TPR plays an important role in quality control of mRNA trafficked on the NXF1 pathway
  • U2AF2 protein facilitates RNA nuclear export by facilitating the formation of a messenger ribonucleoprotein export complex that contains both the NXF1 receptor and the RNA substrate
  • NXT1/NXF1 recognizes bulk mRNAs through combinatorial use of the distinct RNA binding domains
  • sNXF1 can replace NXT1 to enhance the expression of CTE-containing mRNA and promote its association with polyribosomes
  • SUN1 functions in mammalian mRNA export through the NXF1-dependent pathway, and this interaction SUN1-NXF1is at least partly regulated by a protein kinase C (PKC)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS