Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NUSAP1 contributors: mct/shn - updated : 23-09-2012
HGNC name nucleolar and spindle associated protein 1
HGNC id 18538
Location 15q15.1      Physical location : 41.624.925 - 41.673.247
Genatlas name nucleolar and spindle-associated protein 1; nucleolar protein ANKT
Synonym name
  • nucleolar protein ANKT
  • nucleolar and spindle-associated protein 1
    • Synonym symbol(s) FLJ13421, LNP, ANKT, SAPL, BM037, PRO0310p1, Q0310, NuSAP1, BM-037, NUSAP
    DNA
    TYPE functioning gene
    STRUCTURE 48.36 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D15S994 - D15S968 - NUSAP1 - D15S641 - D15S132 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 splicing 2437 49.4 441 - 2003 12963707
    11 splicing 2434 49.4 441 liver 2003 12963707
    11 splicing 2465 - 439 - 2003 12963707
    11 splicing 2426 - 426 - 2003 12963707
    9 splicing 2282 - 378 - 2003 12963707
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    cell cycle     cell cycle, S, G2, M
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a SAP-like domain, fot the interaction with chromatin in interphase cells
  • a C-terminal microtubule-binding domain
    • HOMOLOGY
    interspecies ortholog to Nusap1, Mus musculus
    ortholog to nusap1, Danio rerio
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleolus
    text
  • localizes to chromosome arms and chromosome-proximal microtubules during mitosis and to the nucleus, with enrichment in the nucleoli, during interphase (
    • basic FUNCTION
  • a crucial role in spindle microtubule organization
  • its degradation is important to exit from mitosis
  • microtubule-associated protein that plays an important role in spindle assembly
  • role in connecting apoptosis with cell migration, but also is potentially involved in morphogenesis in vertebrates
  • microtubule-stabilizing protein that localizes to chromosome arms and chromosome-proximal microtubules during mitosis and to the nucleus, with enrichment in the nucleoli, during interphase
  • role in gene expression or DNA damage response
    • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
  • dsDNA
    • RNA
    small molecule
    protein
  • NSUN2
  • novel direct target gene of MYC
    • cell & other
  • microtubules
    • REGULATION
    Other cell cycle regulated, restricted to late S/G2 and M phases, undetectable in G1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS