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FLASH GENE
Symbol NUSAP1 contributors: mct/shn - updated : 23-09-2012
HGNC name nucleolar and spindle associated protein 1
HGNC id 18538
Location 15q15.1      Physical location : 41.624.925 - 41.673.247
Genatlas name nucleolar and spindle-associated protein 1; nucleolar protein ANKT
Synonym name
  • nucleolar protein ANKT
  • nucleolar and spindle-associated protein 1
  • Synonym symbol(s) FLJ13421, LNP, ANKT, SAPL, BM037, PRO0310p1, Q0310, NuSAP1, BM-037, NUSAP
    DNA
    TYPE functioning gene
    STRUCTURE 48.36 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D15S994 - D15S968 - NUSAP1 - D15S641 - D15S132 - qter
    Physical map
    LOC390578 15 similar to BLOCK 23 LOC388114 15 LOC388114 LOC388115 15 similar to RIKEN cDNA 2600011L02 LOC146071 15q14 similar to RIKEN cDNA 1810007E14; EST AA238765 DISP2 15q14 dispatched homolog 2 (Drosophila) FLJ14502 15q14 TRAF4 associated factor 1 IVD 15q14-q15 isovaleryl Coenzyme A dehydrogenase KIAA0945 D4ST-1 15q14 isovaleryl Coenzyme A dehydrogenase MGC20481 15q14 hypothetical protein MGC20481 C18B11 15q13.3 C18B11 homolog (44.9kD) AF15Q14 15q14 AF15q14 protein RAD51 15q15.1 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) FLJ10579 15q14 hypothetical protein FLJ10579 GCHFR 15q15 GTP cyclohydrolase I feedback regulatory protein FLJ10634 15q14 hypothetical protein FLJ10634 ZFYVE19 15q14 zinc finger, FYVE domain containing 19 PPP1R14D 15q13.3 protein phosphatase 1, regulatory (inhibitor) subunit 14D SPINT1 15q15 serine protease inhibitor, Kunitz type 1 ARHV 15q13.3 ras homolog gene family, member V VPS18 15q14-q15 vacuolar protein sorting protein 18 DLL4 15q14 delta-like 4 (Drosophila) MGC4504 15q14 hypothetical protein MGC4504 KIAA1259 15q14 hypothetical protein MGC4504 HCP37 15q15.1 cytochrome c, somatic pseudogene LOC388116 15 similar to RIKEN cDNA 6720467C03 MGC33637 15q14 hypothetical protein MGC33637 CHP 15q13.3 hypothetical protein MGC33637 OIP5 15q14 Opa-interacting protein 5 NUSAP1 15q14 nucleolar and spindle associated protein 1 CIA30 KIAA0252 15q14 nucleolar and spindle associated protein 1 ITPKA 15q14-q21 inositol 1,4,5-trisphosphate 3-kinase A LTK 15q15.1-q15.2 leukocyte tyrosine kinase DKFZP727M111 15q14 DKFZP727M111 protein LOC283747 15q14 similar to elongation factor SIII p15 subunit TYRO3 15q15.1-q21.1 TYRO3 protein tyrosine kinase MGA 15q15 MAX gene associated MAPKBP1 15q14 likely ortholog of mouse mitogen activated protein kinase binding proten 1 PLA2G4B 15q11.2-q21.3 phospholipase A2, group IVB (cytosolic) SPTBN5 15q21 spectrin, beta, non-erythrocytic 5 EHD4 15q11.1-q15 EH-domain containing 4 FLJ45651 15q14 FLJ45651 protein LOC388117 15 LOC388117 cPLA2delta LOC255189 15q14 hypothetical protein LOC255189 VPS39 15q14-q15 vacuolar protein sorting 39 (yeast) DKFZP564G2022 15q14 DKFZP564G2022 protein GANC 15q15.1-q15.2 glucosidase, alpha; neutral C
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 splicing 2437 49.4 441 - 2003 12963707
    11 splicing 2434 49.4 441 liver 2003 12963707
    11 splicing 2465 - 439 - 2003 12963707
    11 splicing 2426 - 426 - 2003 12963707
    9 splicing 2282 - 378 - 2003 12963707
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    cell cycle     cell cycle, S, G2, M
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a SAP-like domain, fot the interaction with chromatin in interphase cells
  • a C-terminal microtubule-binding domain
  • HOMOLOGY
    interspecies ortholog to Nusap1, Mus musculus
    ortholog to nusap1, Danio rerio
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleolus
    text
  • localizes to chromosome arms and chromosome-proximal microtubules during mitosis and to the nucleus, with enrichment in the nucleoli, during interphase (
  • basic FUNCTION
  • a crucial role in spindle microtubule organization
  • its degradation is important to exit from mitosis
  • microtubule-associated protein that plays an important role in spindle assembly
  • role in connecting apoptosis with cell migration, but also is potentially involved in morphogenesis in vertebrates
  • microtubule-stabilizing protein that localizes to chromosome arms and chromosome-proximal microtubules during mitosis and to the nucleus, with enrichment in the nucleoli, during interphase
  • role in gene expression or DNA damage response
  • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
  • dsDNA
  • RNA
    small molecule
    protein
  • NSUN2
  • novel direct target gene of MYC
  • cell & other
  • microtubules
  • REGULATION
    Other cell cycle regulated, restricted to late S/G2 and M phases, undetectable in G1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS