Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NUPL2 contributors: mct - updated : 08-03-2008
HGNC name nucleoporin like 2
HGNC id 17010
Location 7p15      Physical location : 23.221.445 - 23.240.629
Synonym name nucleoporin-like protein 1
Synonym symbol(s) NLP1, CG1
DNA
TYPE like-sequence
STRUCTURE 19.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status provisional
Physical map
NDUFA5 7q31.33 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa NUPL2 7p15 nucleoporin like 2 LOC392004 7 similar to 60S ribosomal protein L12 ASB15 7q31.31 ankyrin repeat and SOCS box-containing 15 GPNMB 7p15 glycoprotein (transmembrane) nmb ASNS 7q21.3 asparagine synthetase LOC392780 7 similar to cardiac leiomodin DRCTNNB1A 7p15.3 similar to cardiac leiomodin C7orf30 7p15.3 chromosome 7 open reading frame 30 WASL 7q31.3 Wiskott-Aldrich syndrome-like IMP-3 7p11 IGF-II mRNA-binding protein 3 LOC392751 7 LOC392751 LOC286031 8p23.1 hypothetical protein LOC286031 LOC392752 7 similar to seven transmembrane helix receptor LOC392753 7 similar to olfactory receptor GA_x6K02T2PVTD-14054886-14053957 OCM 7p13-p11 oncomodulin HYAL4 7q31.3 hyaluronoglucosaminidase 4 SBBI26 7p15.3 SBBI26 protein LOC392642 7 similar to Neuronal protein 3.1 (p311 protein) LOC392643 7 hypothetical gene supported by BC026177 TRA2A 7p15.3 transformer-2 alpha KPI2 7q22.1 transformer-2 alpha NUPL2 7p15 nucleoporin like 2 SPAM1 7q31.3 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) LOC392644 7 hypothetical gene supported by BC022025; NM_003993 GPNMB 7p15 glycoprotein (transmembrane) nmb LOC90693 7p15.3 alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetyl-glucosaminyltransferase-like MIST1 7q22.1 class II bHLH protein MIST1 DKFZP434B0335 7q22.1 DKFZP434B0335 protein C7orf30 7p15.3 chromosome 7 open reading frame 30 IMP-3 7p11 IGF-II mRNA-binding protein 3 LOC392981 7 similar to RIKEN cDNA 6332401O19 gene LOC340277 BRI3 7q22.1 brain protein I3 STK31 7p15.3 serine/threonine kinase 31 LOC55971 7q22.1 insulin receptor tyrosine kinase substrate
regionally located located in the DFNA5 region
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1778 - 423 - Kendirgi (2005)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumearinnercochlea highly
Nervousnerve   highly
Reproductivefemale systemovary   
Urinarybladder   highly
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative zinc finger, CCCH type
  • a C3H1-type zinc finger
  • HOMOLOGY
    interspecies homolog to murine Nupl2
    Homologene
    FAMILY
    CATEGORY signaling , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • porin activity
  • participates in the docking of HIV-Vpr at the nuclear envelope, which may contribute to the disruption of the nuclear envelope import of the viral DNA
  • required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling sensory transduction/hearing
    a component NUP155, GLE1, and nucleoporin NUPL2 form a heterotrimeric complex (Zhang 2008)
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacts with CRM1
  • interacts with the Rev nuclear export signal
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS