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FLASH GENE
Symbol NUP50 contributors: mct - updated : 29-12-2016
HGNC name nucleoporin 50kDa
HGNC id 8065
Location 22q13.31      Physical location : 45.559.725 - 45.583.888
Synonym name nuclear pore-associated protein 60 kDa-like
Synonym symbol(s) NPAP60L, MGC39961
DNA
TYPE functioning gene
STRUCTURE 24.17 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text with multiple transcripts (I,P)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 5051 - 440 - -
8 - 5225 - 468 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
N terminal sequence similar to rat Npap60 and yeast Nup2p,and three FG repeats
HOMOLOGY
interspecies homolog to rattus Npap60
Homologene
FAMILY
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
intracellular,nuclear envelope,pore
basic FUNCTION involved in the differentiation of spermatocytes in spermatozoa (testis form)
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
  • predominantly interacted with transcriptionally active genes inside the nucleoplasm, in particular those involved in developmental regulation and the cell cycle
  • interaction between NUP50 and a region in the unique N-terminal region of NUP153 is critical for the nuclear pore localization of NUP50
  • cell & other i5 nuclear pore associated
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS