Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NUP43 contributors: mct - updated : 14-12-2017
HGNC name nucleoporin 43kDa
HGNC id 21182
Location 6q25.1      Physical location : 150.045.458 - 150.067.688
Synonym name
  • nup107-160 subcomplex subunit Nup43
  • Synonym symbol(s) bA350J20.1, FLJ13287, p42
    DNA
    TYPE functioning gene
    STRUCTURE 22.26 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    SASH1 6q24.3 formyltetrahydrofolate synthetase domain containing 1 LOC340151 6q24.3 similar to laminin receptor 1 (ribosomal protein SA); P40-3, functional; P40-8, functional; laminin receptor 1 (67kD, ribosomal protein SA) UST 6q24.3-q25.1 uronyl-2-sulfotransferase MAP3K7IP2 6q25.1-q25.3 mitogen-activated protein kinase kinase kinase 7 interacting protein 2 LOC340152 6q24.3 similar to hypothetical protein D730019B10 PPIL4 6q24-q25 peptidylprolyl isomerase (cyclophilin)-like 4 C6orf72 6q24.3 chromosome 6 open reading frame 72 LOC389433 6 LOC389433 KATNA1 6q25.1 katanin p60 (ATPase-containing) subunit A 1 LATS1 6q24-q25.1 LATS, large tumor suppressor, homolog 1 (Drosophila) NUP43 6q24.3 nucleoporin 43kDa PCMT1 6q22.3-q24 protein-L-isoaspartate (D-aspartate) O-methyltransferase LRP11 6q24.3 low density lipoprotein receptor-related protein 11 RAET1E 6q25 retinoic acid early transcript 1E ULBP2 6q25 UL16 binding protein 2 ULBP1 6q25 UL16 binding protein 1 LOC345829 6q24.3 similar to Transcription factor BTF3 (RNA polymerase B transcription factor 3) LOC391980 6 similar to UL16 binding protein 1; alcan-beta RAET1L 6q25 retinoic acid early transcript 1L PHBP1 6q25 prohibitin pseudogene 1 ULBP3 6q25 UL16 binding protein 3 PPP1R14C 6q24.3-q25.3 protein phosphatase 1, regulatory (inhibitor) subunit 14C RNU4P1 6q25.1 RNA, U4 small nuclear pseudogene 1 (U4/7) LOC389434 6 similar to iodotyrosine dehalogenase protein PLEKHG1 6q25.1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 FTHFSDC1 6q25.1 formyltetrahydrofolate synthetase domain containing 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 3894 42 380 - 2015 26391640
    - - 2998 42 380 - 2015 26391640
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines ovarian carcinoma
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a nucleoporin domain
  • six WD40 repeats
  • secondary structure adopts a seven-bladed beta-propeller fold
    mono polymer complex
    HOMOLOGY
    interspecies homolog to murine 2610529I12Rik
    Homologene
    FAMILY
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,chromatin/chromosome,kinetochore
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • nuclear pore complex
  • may mediate the assembly of subdomains of the NPC or facilitate the interaction of transport complexes with the NPC
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • important component in the NUP107 subcomplex of NPC
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct interaction of NUP43 with NUP85
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • NUP37, NUP43, and NUP188 are novel candidate genes for cardiovascular disease
  • Marker
    Therapy target
    ANIMAL & CELL MODELS