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FLASH GENE
Symbol NUP160 contributors: mct/pgu - updated : 29-05- 201
HGNC name nucleoporin 160kDa
HGNC id 18017
Location 11p11.2      Physical location : 47.799.670 - 47.870.057
Synonym name
  • histidine acid phosphatase
  • nuclear pore complex protein Nup160
  • Synonym symbol(s) KIAA0197, FLJ22583, MGC150678, MGC150679, NUP120, DKFZp686M14102
    DNA
    TYPE functioning gene
    STRUCTURE 70.39 kb     36 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    36 - 5383 160 1436 - 2001 11684705
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    intracellular,nuclear envelope,pore
    text close to the nuclear envelope
    basic FUNCTION
  • histidine acid phosphatase, binding proteins to the nuclear pore complex
  • NUP107-160 complex is dynamic in mitosis and promotes spindle assembly in a manner that is distinct from its functions at interphase nuclear pores
  • NUP107-160 subcomplex is stable throughout the cell cycle, and phosphorylation does not affect interactions within the NUP107-160 subcomplex, but regulates the association of the subcomplex with the NPC and other proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • NUP107-160 complex interacts with CENPF, but CENPF only moderately contributes to its targeting to kinetochores
  • KPNB1 forms a high-molecular-weight complex with both AHCTF1 and the NUP107-160 complex in cytosol
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NUP107-160 interacts with the gamma-tubulin ring complex (gamma-TuRC), an essential and conserved microtubule nucleator, and recruits gamma-TuRC to unattached kinetochores
  • N terminus of POM121 directly binds the beta-propeller regions of NUP155 and NUP160
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    alterations in specific proteins (NDC1, NUP160, NUP153 and NUP93) in ischaemic and dilated human heart
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS