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FLASH GENE
Symbol NUDT5 contributors: mct - updated : 23-03-2013
HGNC name nudix (nucleoside diphosphate linked moiety X)-type motif 5
HGNC id 8052
Location 10p14      Physical location : 12.209.573 - 12.238.143
Synonym name adenosine 5'-diphosphosugar pyrophosphatase
Synonym symbol(s) YSA1H, HYSAH1, HSP115
EC.number 3.6.1.13 /3.6.1.58
DNA
TYPE anonymous DNA segment
STRUCTURE 28.57 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1224 - 219 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Hearing/Equilibriumearinnercochlea highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a Nudt/MuT domain (Nudix)
HOMOLOGY
interspecies homolog to murine cleaning gene Nud15
homolog to yeast S.cerevisiae YSA1
Homologene
FAMILY superfamily of Nudix hydrolases
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
basic FUNCTION
  • NDP- sugar hydrolase whose function is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the accumulation of intermediates biochemical pathways in mouse
  • eliminating toxic nucleotides from the cell and regulating the levels of important signaling nucleotides and their metabolites
  • is an ADP-ribose (ADPR) pyrophosphatase (ADPRase) that plays important roles in controlling the intracellular levels of ADPR and preventing non-enzymatic ADP-ribosylation of proteins by hydrolyzing ADPR to AMP and ribose 5prime-phosphate
  • potentially eliminates various oxidized deoxyribonucleoside diphosphates from the nucleotide pool and prevents their toxic effects
  • has an intrinsic activity to cleave ADP sugars to AMP and sugar phosphate, possesses the ability to degrade 8-oxo-dGDP to the monophosphate
  • has the potential to prevent errors during DNA replication
  • hydrolyzes various modified nucleoside diphosphates including 8-oxo-dGDP, 8-oxo-dADP and ADP-ribose (ADPR)
  • may play significant roles in regulating the G1-S transition in mammalian cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS detoxification
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • magnesium
  • protein
    cell & other
    REGULATION
    activated by nitric oxide (NO activates NUDT5 through ADP-ribosylation at cysteine residues of the enzyme in macrophages) (
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS