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FLASH GENE
Symbol NUDT4 contributors: - updated : 02-11-2006
HGNC name nudix (nucleoside diphosphate linked moiety X)-type motif 4
HGNC id 8051
Location 12q21      Physical location : 93.771.700 - 93.797.022
Synonym symbol(s) DIPP2, KIAA0487
DNA
TYPE functioning gene
SPECIAL FEATURE
text CAG codon within an AGCAG pentamer, offering adjacent alternate intronic 3' -boundaries (intron boundary skidding).
an array of alternative polyadenylation signals
STRUCTURE 25.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
text multiple transcripts differing by their 3' utr (Caffrey)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1500 20.3 180 - Caffrey
- - - 20.4 181 fetal kidney Caffrey
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinepancreas    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Nudt/MutT motifwith a GX(2)GX(6)G carboxy extension
  • HOMOLOGY
    interspecies ortholog to E.coli MutT (nudt)
    ortholog to murine Nudt4
    ortholog to rattus
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • diphosphoinositol polyphosphates phosphohydrolase whose function is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the accumulation of intermediates in biochemical pathways in mouse
  • involved in intracellular trafficking
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • magnesium
  • manganese
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS