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FLASH GENE
Symbol NUDT3 contributors: - updated : 02-11-2006
HGNC name nudix (nucleoside diphosphate linked moiety X)-type motif 3
HGNC id 8050
Location 6p21.2      Physical location : 34.256.001 - 34.360.441
Synonym name
  • nudix motif 3
  • diphosphoinositol polyphosphate phosphohydrolase 1
  • Synonym symbol(s) DIPP, DIPP1
    EC.number 3.6.1.52
    DNA
    TYPE functioning gene
    STRUCTURE 104.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map pter - D6S1558 - D6S1542 - NUDT3 - D6S1645 - D6S291 - D6S1576 - D6S1562 - D6S1575 - D6S1616 - cen
    Authors GeneMap (98)
    Physical map
    LYPLA2P1 6p21.31 lysophospholipase II pseudogene 1 KIFC1 6p21.3 kinesin family member C1 PHF1 6p21.3 PHD finger protein 1 C6orf82 6pter-p21.31 chromosome 6 open reading frame 82 MGC23166 BAK1 6p21.3 BCL2-antagonist/killer 1 ITPR3 6p21 inositol 1,4,5-triphosphate receptor, type 3 C6orf125 6p21.31 chromosome 6 open reading frame 125 IHPK3 6p2131-p21.2 inositol hexaphosphate kinase 3 LEMD2 6p21.31 LEM domain containing 2 MLN 6p21.3 motilin GRM4 6p21.3 glutamate receptor, metabotropic 4 LOC389381 6 LOC389381 LOC391914 6 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) CYCSL1 6p21.31 cytochrome c, somatic-like 1 HMGA1 6p21.3 high mobility group AT-hook 1 MGC57858 6p21.31 hypothetical protein MGC57858 LOC391915 6 hypothetical gene supported by U12465; NM_007209 NUDT3 6p21.2 nudix (nucleoside diphosphate linked moiety X)-type motif 3 RPS10 6p21.3 ribosomal protein S10 PACSIN1 6p21.3 protein kinase C and casein kinase substrate in neurons 1 SPDEF 6p21.3 SAM pointed domain containing ets transcription factor C6orf106 6p21.31 chromosome 6 open reading frame 106 MGC4614 6p21.31 hypothetical protein MGC4614 LOC391916 6 hypothetical gene supported by BC001032; NM_001014 SNRPC 6p21.2 small nuclear ribonucleoprotein polypeptide C C6orf107 6p21 chromosome 6 open reading frame 107 TAF11 6p21 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa ANKS1 6p21.31 ankyrin repeat and SAM domain containing 1 TCP11 6p21.2 t-complex 11 (mouse) CEGF3 6p21.3 CUB domain and EGF-like repeat containing 3
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • MuT domain, metabolizing some nucleoside phosphates that may play a role in signal transduction
  • also putatively involved in dephosphorylation of 8-oxo-dGTP which causes AT to GT transversion mutations
  • HOMOLOGY
    interspecies homolog to murine cleaning gene putative
    Homologene
    FAMILY
  • Nudix hydrolase family
  • DIPP subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • diphosphoinositol polyphosphate phosphohydrolase whose function is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the accumulation of intermediates in biochemical pathways in mouse
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS detoxification
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Mg2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS