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FLASH GENE
Symbol NUDT2 contributors: - updated : 02-11-2006
HGNC name nudix (nucleoside diphosphate linked moiety X)-type motif 2
HGNC id 8049
Location 9p13      Physical location : 34.329.503 - 34.343.695
Synonym name
  • Ap4A hydrolase
  • diadenosine tetraphosphatase
  • Synonym symbol(s) APAH1, MGC10404
    EC.number 3.6.1.17
    DNA
    TYPE functioning gene
    STRUCTURE 14.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D9S165 - D9S1878 - CNTFR - IL11RA - NUDT2 - GALT - D9S163 - CHH - D9S50 - cen
    Authors Mc Lennan (98)
    Physical map
    UBE2R2 9p11.2 ubiquitin-conjugating enzyme E2R 2 UBAP2 9p13.2 ubiquitin associated protein 2 KIAA1892 9p11.2 KIAA1892 LOC340499 9p13.2 similar to inosine monophosphate dehydrogenase 1 isoform b; sWSS2608 UBAP1 9p22-p21 ubiquitin associated protein 1 C9orf48 9p13.2 chromosome 9 open reading frame 48 KIF24 9p13.2 kinesin family member 24 NUDT2 9p13 nudix (nucleoside diphosphate linked moiety X)-type motif 2 KIAA1161 9p11.2 KIAA1161 C9orf24 9p11.2 chromosome 9 open reading frame 24 C9orf25 9p11.2 chromosome 9 open reading frame 25 DNAI1 9p13.3 dynein, axonemal, intermediate polypeptide 1 UNQ470 9p13.2 GAAI470 CNTFR 9p21-p13 ciliary neurotrophic factor receptor C9orf23 9p11.2 chromosome 9 open reading frame 23 DCTN3 9p13 dynactin 3 (p22) LOC138715 9p13.2 similar to E2F binding protein OPRS1 9 opioid receptor, sigma 1 GALT 9p13.3 galactose-1-phosphate uridylyltransferase IL11RA 9p13 interleukin 11 receptor, alpha CCL27 9p13 chemokine (C-C motif) ligand 27 LOC389714 9 LOC389714 CCL19 9p13 chemokine (C-C motif) ligand 19 CCL21 9p13 chemokine (C-C motif) ligand 21 LOC259308 9p12 DKFZP434J193-like pseudogene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1060 16 147 - -
    - splicing 989 16 147 - -
    - splicing 947 16 147 - -
    lacking a 5' non coding exon
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a modification of the MuT sequence motif found in certain nucleotide pyrophosphatases, potentially involved in dephosphorylation of the mitogenic 2-hydroxy-d ATP and/or preventing accumulation od dATP
  • HOMOLOGY
    interspecies homolog to murine cleaning gene (putative)
    ortholog to murine Nudt2
    Homologene
    FAMILY Nudix hydrolase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • hydrolase
  • diadenosine 5',5'' - P1,P4 -tetraphosphate hydrolase whose function is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the accumulation of intermediates in biochemical pathways in mouse
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS