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Symbol NUDT18 contributors: mct - updated : 26-06-2017
HGNC name nudix hydrolase 18
HGNC id 26194
Location 8p21.3      Physical location : 21.964.382 - 21.966.932
Synonym name
  • 2-hydroxy-dADP phosphatase
  • 7,8-dihydro-8-oxoguanine phosphatase
  • mutT homolog 3
  • Synonym symbol(s) MTH3
    EC.number 3.6.1.58
    DNA
    TYPE functioning gene
    STRUCTURE 3.48 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1519 - 323 - 2012 22556419
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • is specifically active against 8-oxo-dGDP and hardly cleaves 8-oxo-dGTP
  • can degrade 8-oxo-GDP as efficiently as 8-oxo-dGDP, which is in contrast to the finding that NUDT1 and NUDT15 show a limited activity against the ribonucleotide counterpart, 8-oxo-GTP
  • NUDT1, NUDT15, NUDT18 may function together to help maintain the high fidelity of DNA replication and transcription under oxidative stress
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS