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Symbol NUDT16 contributors: np/mct - updated : 17-05-2017
HGNC name nudix (nucleoside diphosphate linked moiety X)-type motif 16
HGNC id 26442
Location 3q22.1      Physical location : 131.100.514 - 131.107.673
Synonym name
  • nudix motif 16
  • nucleoside diphosphate-linked moiety X motif 16
  • U8 snoRNA-decapping enzyme
  • U8 snoRNA-binding protein H29K
  • Synonym symbol(s) FLJ34034, FLJ36248, FLJ31265, H29K
    EC.number 3.6.1.62/3.6.1.64
    DNA
    TYPE functioning gene
    STRUCTURE 7.16 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 5943 - 159 - 2010 20385596
    3 - 6117 - 195 - 2010 20385596
    2 - 930 - 227 - 2010 20385596
    EXPRESSION
    Rna function NUDT16 mRNA was detected in all tissues examined and the highest expression was observed in lung and kidney
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer dimer
    HOMOLOGY
    interspecies homolog to Xenopus laevis X29
    Homologene
    FAMILY
  • NUDIX hydrolase superfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text
  • mostly localized in the nucleus, and especially in the nucleolus
  • abundance in both cytoplasm and nucleus
  • basic FUNCTION
  • nuclear nucleoside diphosphatase proteins localized within foci in the nucleolus and nucleoplasm
  • may be the nuclear counterparts of the cytoplasmic decapping machinery, localized in specialized bodies involved in RNA decay
  • plays a pivotal role in U8 snoRNA stability
  • with ITPA play a dual protective role for eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals (MID: 20081199)
  • hydrolyzes purine nucleoside diphosphates to the corresponding nucleoside monophosphates
  • may function mainly in the nucleus to protect cells from deleterious effects of (d)ITP
  • has an essential role in the maintenance of genome stability
  • like DCP2, also regulates the stability of a subset of mRNAs including a member of the motin family of proteins involved in angiogenesis, Angiomotin-like 2 (AMOTL2)
  • having pleiotropic decapping activity
  • six Nudix proteins as well as both DCP2 and NUDT16 could hydrolyze the cap of an unmethylated capped RNA, indicating that decapping enzymes may be less constrained for the presence of the methyl moiety
  • multiple Nudix family hydrolases may function in mRNA decapping and mRNA stability
  • mRNA decapping enzyme, with a role as an "housecleaning" enzyme specialized in the removal of hazardous (deoxy)inosine diphosphate from the nucleotide pool
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • appears as a dimer whose formation generates a positively charged trench to accommodate substrate-binding (
  • omplex with its product inosine monophosphate (IMP) (
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ITP-binding protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    induces accumulation of single strand breaks in nuclear DNA and growth arrest in human cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS