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FLASH GENE
Symbol NUDT15 contributors: mct - updated : 26-06-2018
HGNC name nudix hydrolase 15
HGNC id 23063
Location 13q14.2      Physical location : 48.611.702 - 48.621.282
Synonym symbol(s) MTH2, NUDT15D
EC.number 3.6.1.9
DNA
TYPE functioning gene
STRUCTURE 15.18 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 2122 - 164 - 2016 27308664
2 - 934 - 145 - 2016 27308664
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • can degrade both 8-oxo-dGTP and 8-oxo-dGDP, although the intrinsic enzyme activity of NUDT15 is considerably lower than that of NUDT1
  • NUDT1, NUDT15, NUDT18 may function together to help maintain the high fidelity of DNA replication and transcription under oxidative stress
  • is a pharmacogenetic determinant for thiopurine-induced leukopenia in diverse populations
  • is not a biologically relevant 8-oxo-dGTPase, and NUDT1 is the most prominent sanitizer of the cellular deoxyribonucleoside triphosphates (dNTPs) pool known to date
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physical interaction between PCNA and MutT homolog2 (NUDT15), a new member of the MutT-related proteins that hydrolyzes 8-oxo-7,8-dihydrodeoxyguanosine triphosphate (8-oxo-dGTP)
  • NUDT15 ablation potentiated induction of the DNA damage checkpoint and cancer cell death by 6-thioguanine
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to variation of tolerance to thiopurine drugs
    Variant & Polymorphism other
  • NUDT15 polymorphisms are major determinants of tolerance to thiopurine drugs used in leukemias and nonmalignant immunologic disorders
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS