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Symbol NUDT12 contributors: - updated : 13-11-2006
HGNC name nudix (nucleoside diphosphate linked moiety X)-type motif 12
HGNC id 18826
Location 5q21.2      Physical location : 102.884.556 - 102.898.490
Synonym name
  • nucleoside diphosphate linked moiety X-type motif 12
  • nudix motif 12
  • Synonym symbol(s) DKFZP761I172
    EC.number 3.6.1.22
    DNA
    TYPE functioning gene
    STRUCTURE 13.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Skin/Tegumentskin    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an ankyrin repeat in its N-terminal half
  • a consensus Nudix (Nudt) motif
  • an NADH diphosphatase-like sequence in its C-terminal half
  • HOMOLOGY
    interspecies homolog to murine Nudt12
    Homologene
    FAMILY
  • NUDIX family of hydrolases
  • NudC subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • having hydrolase activity
  • may act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • magnesium
  • manganese
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS