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FLASH GENE
Symbol NUDCD2 contributors: mct/npt - updated : 20-05-2010
HGNC name NudC domain containing 2
HGNC id 30535
Location 5q34      Physical location : 162.880.586 - 162.887.143
Synonym name NudC-like protein 2
Synonym symbol(s) DKFZp686E10109, NUDCL2
DNA
TYPE functioning gene
STRUCTURE 6.56 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 977 - 157 - Yang (2010)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • NudC family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text localized to the centrosome in interphase, and spindle poles and kinetochores during mitosis (Yang 2010)
    basic FUNCTION
  • play a role in the regulation of the LIS1/dynein pathway (Yang 2010)
  • regulates the PAFAH1B1/dynein pathway by stabilizing PAFAH1B1 with Hsp90 chaperone (Yang 2010)
  • may act as an adaptor protein to facilitate the interaction between Hsp90 and its potential client protein, PAFAH1B1 (Yang 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a complex with PAFAH1B1 and Hsp90 (Yang 2010)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS