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FLASH GENE
Symbol NUCKS1 contributors: mct/npt - updated : 12-01-2010
HGNC name nuclear casein kinase and cyclin-dependent kinase substrate 1
HGNC id 29923
Location 1q32.1      Physical location : 205.681.946 - 205.719.372
Synonym name
  • nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate variant
  • potential LAG1 interactor
  • Synonym symbol(s) FLJ21480, JC7, NUCKS, FLJ32016, FLJ38536, P1
    DNA
    TYPE functioning gene
    STRUCTURE 37.41 kb     7 Exon(s)
    regulatory sequence cytosine-phosphate-guanine/HTF
    Binding site
    text structure contains two Inr elements, two GC boxes, and one consensus-binding site for E2F-1
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 6453 27 243 - Grundt (2002)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
     stomach   highly
    Reproductivefemale systemovary  highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • DNA-binding domain
  • two regions of highly charged, basic residues, which were identified as potential nuclear localization signals (NLS1 and 2), capable of translocating green fluorescent protein (GFP) into the nucleus (but NLS1 is the main nuclear localization signal) (Grundt 2007)
  • several consensus phosphorylation sites for cyclin-dependent kinases and CK-2
  • 19 phosphorylation sites (Wiśniewski 2008)
  • secondary structure low level of alpha helical content and substantial amounts of beta turn structures
    conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • located in the nuclei in proliferating cells in interphase of the cell cycle, but was distributed throughout the cytoplasm in mitotic cells
  • distributed throughout the cytoplasm in mitotic cells and targeted to the reforming nuclei in late telophase of the cell cycle
  • basic FUNCTION
  • may have the highest ratio of modified to unmodified residues of any protein so far described (Wiśniewski 2008)
  • DNA-binding protein distributed throughout the cytoplasm in mitotic cells and targeted to the reforming nuclei in late telophase of the cell cycle
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA DNA-binding
    RNA
    small molecule
    protein
  • phosphorylated by CDK1 during mitosis of the cell cycle
  • binds to importin alpha3 and importin alpha5, suggesting that the nuclear targeting of NUCKS1 follows a receptor-mediated and energy-dependent import mechanism
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS