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FLASH GENE
Symbol NUCB2 contributors: mct - updated : 18-05-2012
HGNC name nucleobindin 2
HGNC id 8044
Location 11p15.1      Physical location : 17.298.285 - 17.353.069
Genatlas name nesfatin
Synonym name
  • DNA-binding/EF-hand/leucine zipper protein
  • DNA-binding protein NEFA
  • gastric cancer antigen Zg4
  • Synonym symbol(s) NEFA
    DNA
    TYPE functioning gene
    STRUCTURE 54.78 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - D11S1890 - OR7E14P - RPS13 /PIK3C2A - D11S921 - NUCB2 - KCNJ11 - ABCC8 - D11S902 - cen
    Authors Caldwell (01)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 1612 - 420 - 2001 11306805
    EXPRESSION
    Rna function mRNA is detected in the paraventricular nucleus of the hypothalamus
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Lymphoid/Immunethymus   highly
    nervousbraindiencephalon   
    Nervousbrainmidbrainhypothalamus   Homo sapiens
    Reproductivefemale systembreastmammary gland highly
     male systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    Respiratoryepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a basic acidic AA rich putative DNA binding domain with a potential nuclear localization signal (NLS)
  • two helix-loop-helix (HLH) motifs, that exhibit two EF-hand calcium binding motifs
  • an acidic AA rich region between the two HLH motifs and a leucine zipper motif
  • NUCB1 and NUCB2, two highly homologous calcium-binding proteins, share a common motif with CCDC88A for Galpha(i) binding and activation
  • HOMOLOGY
    interspecies homolog to murine Nucb2
    intraspecies homolog to calmodulin
    Homologene
    FAMILY nucleobindin family
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • may be having a role in calcium homeostasis
  • NUCB2/ERAP1 complexes, which associate with TNFRSF1A play an important role in mediating TNFRSF1A release to the extracellular compartment
  • NUCB1 and NUCB2 are multifunctional proteins that interact with Ca(2+), nucleic acids and various regulatory proteins in different signaling pathways
  • novel action, in addition to its anorexigenic effects, to stimulate autonomic nervous system activity
  • NUCB2-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway
  • mediator of anorexia and catabolism in the central nervous system
  • role for NUCB2 in beta-cell function and a potential involvement in diabetic pathology
  • anorexigenic signal, acting in a leptin-independent manner
  • indispensable role of NUCB2 in the central networks driving puberty onset, a function that may contribute to its functional coupling to energy homeostasis
  • could play an important role in the protection against the development of obesity in male subjects and might have an influence on energy homeostasis
  • play an important role in metabolic control through its anorexigenic and anti-hyperglycemic effects
  • adipocytokine which exerts not only anorexigenic but also hypertensive roles through acting on hypothalamus melanocortin-3/4 receptors
  • modulates blood pressure through directly acting on peripheral arterial resistance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    a component NUCB2/ERAP1 complexes
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with necdin (necdin with NUCB2 might be involved in Ca(2+) homeostasis in neuronal cytoplasm)
  • its functions could be modulated by caspase-mediated cleavage in apoptosis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    by estrogens and plays an important role, especially in the process of metastasis, in breast carcinomas
    Susceptibility to obesity in men
    Variant & Polymorphism SNP
  • rs1330, rs214101 and rs757081 are associated with obesity in men
  • Candidate gene
    Marker potent prognostic factor in breast cancer
    Therapy target
    ANIMAL & CELL MODELS