motifs/domains
| N-terminal fragment (first 220 AAs) comprised the putative DNA binding region |
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three evolutionarily conserved N-linked glycosylation sites within its carboxyl luminal domaina signal peptide |
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five or more CAG repeats |
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NUCB1 and NUCB2, two highly homologous calcium-binding proteins, share a common motif with CCDC88A for Galpha(i) binding and activation |
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a Ca(2+)-binding domain which is unstructured in the absence of Ca2+ and folds upon Ca2+ addition |
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Ser-378 of GXSXG motif, Asp-328 of DTG motif, and His-339 form the "catalytic triad," locating the enzyme active site in the C-terminal region , and C-terminal fragment contained the two EF-hand motifs, G protein-binding site, and the leucine zipper domain |
SUBCELLULAR LOCALIZATION
| extracellular
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytoskeleton,microtubule
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text
| in the cis-Golgi, tightly associated with the luminal side of the membrane |
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calcium (Ca2+) binding protein found in both Golgi and cytoplasm |
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Ca(++)-binding protein found in the cytoplasm where it binds different Galpha subunits, in the Golgi lumen where it constitutes a major Ca(++) storage pool, and outside the cell |
basic FUNCTION
| playing a role in calcium homeostasis |
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playing a role as a housekeeping gene |
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major calcium-binding protein of the golgi that may have a role in calcium homeostasis |
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Golgi-localized negative feedback regulator in the ATF6-mediated branch of the unfolded protein response (suppresses the S1P-mediated cleavage activation of ATF6 in the Golgi apparatus) |
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participates in Ca2+ storage in the Golgi, as well as in other biological processes that involve DNA-binding and protein-protein interactions |
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NUCB1 and NUCB2 are multifunctional proteins that interact with Ca(2+), nucleic acids and various regulatory proteins in different signaling pathways |
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plays a role in receptor trafficking |
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Golgi-localized soluble protein with a signal peptide and multiple functional domains, and negative regulator of the unfolded protein response that activates various endoplasmic reticulum (ER)-originating signaling pathways |
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multidomain calcium-binding protein, that might interact with heterotrimeric G protein alpha subunits |
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cytoplasmic NUCB1 might function to regulate heterotrimeric G protein trafficking and G protein-coupled receptor-mediated signal transduction pathways |
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prevent islet amyloid polypeptide (hIAPP) fibril formation and disaggregate preexisting hIAPP fibrils, and may offer a new approach to inhibiting amyloid formation and disaggregating amyloid fibrils |
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is a serine protease with its active site catalytic triad present in the C-terminal domain |
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acting as a Ca2+-binding protein in Zn2+-bound form and as a protease in Zn2+-free formas |
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EF-hand containing Ca2+ binding serine protease |