Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NUBP1 contributors: mct - updated : 27-04-2011
HGNC name nucleotide binding protein 1 (MinD homolog, E. coli)
HGNC id 8041
Location 16p13.1      Physical location : 10.837.697 - 10.863.208
Synonym symbol(s) NBP, NBP1, MGC117406, MGC130052, MGC130053, NBP35
DNA
TYPE functioning gene
STRUCTURE 25.51 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map D16S407 - D16S414 - PRM2 - PRM1 - NUBP1 - D16S3078 - D16S3114 - cen
Authors GeneMap
Physical map
GRIN2A 16p13.2 glutamate receptor, ionotropic, N-methyl D-aspartate 2A ATF7IP2 16p13.2 activating transcription factor 7 interacting protein 2 EMP2 16p13.2 epithelial membrane protein 2 FLJ32871 16p13.2 hypothetical protein FLJ32871 NUBP1 16p13.1 nucleotide binding protein 1 (MinD homolog, E. coli) LOC283816 16p13.2 similar to ARHGAP21 protein MHC2TA 16p13 MHC class II transactivator DEXI 16p13.2 dexamethasone-induced transcript KIAA0350 16p13.13-p13.3 dexamethasone-induced transcript LOC390674 16 similar to Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1 / hnRNP C2) SOCS1 16p13.13 suppressor of cytokine signaling 1 TNP2 16p13.13 transition protein 2 (during histone to protamine replacement) PRM2 16p13.13 protamine 2 PRM1 16p13.13 protamine 1 MGC24665 16p13.2 hypothetical protein MGC24665 LOC388210 16 similar to CG15828-PA LOC388211 16 hypothetical gene supported by AK126539 LITAF 16p13.3-p12 lipopolysaccharide-induced TNF factor SNN 16p13 stannin LOC51061 16p13.13 hypothetical protein LOC51061 FLJ21777 16p13.13 hypothetical protein FLJ21777 HSPC055 16p13-p12 zinc-finger protein AY163807 LOC388212 16 LOC388212 DKFZP564M182 16p13.13 DKFZP564M182 protein GSPT1 16p13.13 G1 to S phase transition 1 COX6CP1 16p12 cytochrome c oxidase subunit VIc pseudogene 1 LOC348151 16p13.13 similar to nuclear pore complex interacting protein TNFRSF17 16p13.1 tumor necrosis factor receptor superfamily, member 17 FLJ12363 16p13.13 hypothetical protein FLJ12363 LOC92017 16p13.13 similar to RIKEN cDNA 4933437K13
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1265 - 320 - Suzuki (2004)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestivesalivary gland   highly
Endocrinethyroid   highly
Reproductivemale systemtestis  highly
Respiratorylung   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ATP/GTP binding motif A phosphate binding (P loop)
  • NUBP/MPP alpha and beta motifs
  • C-terminal region is important for nuclear transfer
  • HOMOLOGY
    interspecies homolog to E.coli mrp gene MinD-like
    homolog to murine Nubp1
    Homologene
    FAMILY MRP/NBP35 family of ATP-binding proteins
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • playing a vital role in cell function
  • involved in the proper placement of the division septum
  • having ATP activity
  • implicated with KIFC1 in a common regulatory pathway involved in the control of centrosome duplication in mammalian cells
  • specifically involved in the formation of extramitochondrial Fe/S proteins
  • CELLULAR PROCESS cell cycle, division
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complex with NUBP1, suggesting the existence of a heteromeric P-loop NTPase complex that is required for both cytosolic Fe/S protein assembly and cellular iron homeostasis
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
  • NUBP1 and NUBP2 proteins interact with each other and regulate their function
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    associated with an impaired maturation of the cytosolic Fe/S proteins glutamine phosphoribosylpyrophosphate amidotransferase and iron regulatory protein 1 (ACO1), while mitochondrial Fe/S proteins remained intact
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS