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FLASH GENE
Symbol NTSR2 contributors: mct - updated : 27-05-2013
HGNC name neurotensin receptor 2
HGNC id 8040
Location 2p25.1      Physical location : 11.798.304 - 11.810.329
Synonym name levocabastine-sensitive neurotensin receptor
Synonym symbol(s) NTR2
DNA
TYPE functioning gene
STRUCTURE 11.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainbasal nucleicorpus callosum  
 brainhindbraincerebellum  
 braindiencephalonhypothalamus  
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a short cytoplasmic N-terminal sequence with no clear potential glycosylation sites.
  • a cysteine residue conserved in the human, mouse, and rat proteins in each of the extracellular loops between the 7 transmembrane domains
  • HOMOLOGY
    intraspecies homolog to NTSR1
    Homologene
    FAMILY family 1 of G-protein coupled receptors
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • activating a phosphatidylinositol-calcium second messenger system
  • heterodimerization with NTSR1 may play a physiological role in the regulation of their cell surface density, and hence of their responsiveness to neurotensin, in central nevous system
  • novel function of NTSR2 in the regulation of NTSR1 activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in B cell leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS