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FLASH GENE
Symbol NTSR1 contributors: mct - updated : 27-05-2013
HGNC name neurotensin receptor 1 (high affinity)
HGNC id 8039
Location 20q13.33      Physical location : 61.340.188 - 61.394.122
Synonym name
  • high-affinity levocabastine-insensitive neurotensin receptor
  • Synonym symbol(s) NTSR, NTR, NTR1, NTRH
    DNA
    TYPE functioning gene
    STRUCTURE 53.93 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    ADRM1 20q13.33 adhesion regulating molecule 1 LAMA5 20q13.2-q13.3 laminin, alpha 5 RPS21 20q13.3 ribosomal protein S21 C20orf150 20q13.33 chromosome 20 open reading frame 150 C20orf151 20q13.33 chromosome 20 open reading frame 151 GATA5 20q11.21-q11.22 GATA binding protein 5 RPL7P3 20q13.33 ribosomal protein L7 pseudogene 3 C20orf166 20q13.33 chromosome 20 open reading frame 166 FLJ30313 20q13.33 hypothetical protein FLJ30313 LOC388805 20 LOC388805 FLJ32154 20q13.33 hypothetical protein FLJ32154 SLCO4A1 20q13.33 solute carrier organic anion transporter family, member 4A1 NTSR1 20q13 neurotensin receptor 1 (high affinity) LOC391261 20 similar to putative glycine-rich protein C20orf20 20q13.33 chromosome 20 open reading frame 20 OGFR 20q13 opioid growth factor receptor COL9A3 20q13.3 collagen, type IX, alpha 3 TCFL5 20q13.3 transcription factor-like 5 (basic helix-loop-helix) C20orf143 20q13.33 chromosome 20 open reading frame 143 ARF4P2 20q13.33 ADP-ribosylation factor 4 pseudogene 2 C20orf158 20q13.33 chromosome 20 open reading frame 158 DATF1 20q13.33 death associated transcription factor 1 C20orf11 20q13.33 chromosome 20 open reading frame 11 C20orf59 20q13.33 chromosome 20 open reading frame 59 LOC388806 20 hypothetical gene supported by AK128846 LOC343565 20q13.33 similar to VsaA -like protein C20orf51 20q13.33 chromosome 20 open reading frame 51
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 4158 - 418 - 2000 10690540
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    Nervouscentral   
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    seven transmembrane segments (7TM) receptor
    HOMOLOGY
    Homologene
    FAMILY G protein coupled receptor superfamily
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • may be implicated in dopamine-associated behavioral neurodegenerative and neuropsychiatric disorders
  • heterodimerization with NTSR2 may play a physiological role in the regulation of their cell surface density, and hence of their responsiveness to neurotensin, in central nevous system
  • play a key role in the mediation of the analgesic effects of neuropeptide neurotensin in persistent pain
  • novel function of NTSR2 in the regulation of NTSR1 activity
  • potentially playing inhibitory roles in weak fear memory
  • NTR1-inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterodimerize with NTSR2
    INTERACTION
    DNA
    RNA
    small molecule
    protein ligand NTS
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in B cell leukemia
    tumoral     --over  
    contributes to ductal breast cancer progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential new prognostic biomarker for surgically resected stage I lung adenocarcinomas, as NTSR1 activation was shown to participate in lung cancer progression
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    targeting the NTR1 receptor is a strategy to improve efficacy and outcomes of prostate cancer treatments using radiotherapy
    ANIMAL & CELL MODELS