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FLASH GENE
Symbol NTSR1 contributors: mct - updated : 27-05-2013
HGNC name neurotensin receptor 1 (high affinity)
HGNC id 8039
Location 20q13.33      Physical location : 61.340.188 - 61.394.122
Synonym name
  • high-affinity levocabastine-insensitive neurotensin receptor
    • Synonym symbol(s) NTSR, NTR, NTR1, NTRH
    DNA
    TYPE functioning gene
    STRUCTURE 53.93 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 4158 - 418 - 2000 10690540
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    Nervouscentral   
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		seven transmembrane segments (7TM) receptor
    HOMOLOGY
    Homologene
    FAMILY G protein coupled receptor superfamily
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • may be implicated in dopamine-associated behavioral neurodegenerative and neuropsychiatric disorders
  • heterodimerization with NTSR2 may play a physiological role in the regulation of their cell surface density, and hence of their responsiveness to neurotensin, in central nevous system
  • play a key role in the mediation of the analgesic effects of neuropeptide neurotensin in persistent pain
  • novel function of NTSR2 in the regulation of NTSR1 activity
  • potentially playing inhibitory roles in weak fear memory
  • NTR1-inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterodimerize with NTSR2
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand NTS
  • ADRBK1 phosphorylates NTSR1 only the C-terminal Ser residues, whereas GRK5 phosphorylates Ser and Thr residues located in intracellular loop 3 and the C-terminus
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in B cell leukemia
    tumoral     --over  
    contributes to ductal breast cancer progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential new prognostic biomarker for surgically resected stage I lung adenocarcinomas, as NTSR1 activation was shown to participate in lung cancer progression
    • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    targeting the NTR1 receptor is a strategy to improve efficacy and outcomes of prostate cancer treatments using radiotherapy
    ANIMAL & CELL MODELS