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FLASH GENE
Symbol NTS contributors: mct/npt - updated : 05-02-2010
HGNC name neurotensin
HGNC id 8038
Location 12q21.31      Physical location : 86.268.074 - 86.276.763
Synonym name
  • neuromedin N
  • neurotensin/neuromedin N
  • Synonym symbol(s) NMN-125, NN, NT, NT/N, NTS1
    DNA
    TYPE functioning gene
    STRUCTURE 8.70 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   cAMP
    text structure
  • a proximal promoter cAMP-responsive element (CRE)/AP-1 site and a purine-rich imperfect direct repeat sequence were particularly important for expression, binding both AP-1 and CREB/ATF proteins and crucial for constitutive NTS expression
  • MAPPING cloned Y linked N status confirmed
    Map cen - D12S1708 - D12S1981 - D12S1670 - D12S319 - D12S1667 - D12S1118 - D12S1214E - D12S323 - D12S33 - D12S855 - D12S1444 - NTS - D12S81 - D12S88 - D12S365 - D12S2039 - D12S1719 - D12S1593 - KITLG - D12S1453 - (D12S2009 ,D12S1250E ) - D12S1429 - (D12S1400 ,D12S1152E ) - ATP2B1 - D12S1122 - D12S5316 - D12S82 - qter
    Authors Marondel (96),4st Workshop chrom.12 (97)
    Physical map
    PTPRQ 12q21.2 protein tyrosine phosphatase, receptor type, Q MYF6 12q21 myogenic factor 6 (herculin) MYF5 12q21 myogenic factor 5 LIN7A 12q21 lin-7 homolog A (C. elegans) FLJ21963 12q21.31 FLJ21963 protein PPFIA2 12q21.31 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 HSPC128 12q21.31 HSPC128 protein FLJ22789 12q21.31 hypothetical protein FLJ22789 DKFZp762A217 12q21.31 hypothetical protein DKFZp762A217 LOC390348 12 similar to 60S ribosomal protein L6 (TAX-responsive enhancer element binding protein 107) (TAXREB107) (Neoplasm-related protein C140) LOC387871 12 LOC387871 NTT73 12q21.3-q21.4 LOC387871 LOC390349 12 similar to Small nuclear ribonucleoprotein Sm D2 (snRNP core protein D2) (Sm-D2) LOC144448 12q21.31 similar to CD63 antigen (AD1 antigen) FLJ12303 12q21 hypothetical protein FLJ12303 LOC283393 12q21.31 hypothetical LOC283393 CART1 12q21.3-q22 cartilage paired-class homeoprotein 1 PAMCI 12q21.32 peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor NTS 12q21 neurotensin HGNT-IV-H 12q21 UDP-N-acetylglucosamine:a-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV-homolog HCP30 12q21.33 cytochrome c, somatic pseudogene LOC160420 12q21.33 similar to Makorin 1 FLJ35821 12q21.33 hypothetical protein FLJ35821 DKFZp434N2030 12q21.33 hypothetical protein DKFZp434N2030 KIAA0373 12q21-q22 hypothetical protein DKFZp434N2030 FLJ13615 12q21.33 hypothetical protein FLJ13615 FLJ90492 12q21.33 hypothetical protein FLJ90492 KITLG 12q22 KIT ligand MRPS6P4 12q21 mitochondrial ribosomal protein S6 pseudogene 4 DUSP6 12q21 dual specificity phosphatase 6 TUWD12 12q21.33 TUWD12 CENPC2 12q21.2-q21.33 centromere protein C2, 140kDa GALNT4 12q21.3-q22 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4) ATP2B1 12q21-q23 ATPase, Ca++ transporting, plasma membrane 1 MRPL2P1 12q21.33 ATPase, Ca++ transporting, plasma membrane 1 FLJ25378 12q22 hypothetical protein FLJ25378 MGC26598 12q22 hypothetical protein MGC26598 DSPG3 12q21.3-q22 dermatan sulfate proteoglycan 3 KERA 12q22 keratocan LUM 12q21.3-q22 lumican DCN 12q13.2 decorin
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1241 13 170 - Bean (1992)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestinejejunum highly Homo sapiens
     intestinesmall intestineileum highly Homo sapiens
     stomach    
    Reproductivefemale systembreast    Homo sapiens
    cell lineage
    cell lines
    fluid/secretion secreted
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • tridecapeptide
  • isoforms Precursor neurotensin and neuromedin N are located in the C-terminal region of the precursor (pro-NT/NN) where they are flanked and separated by three Lys -Arg sequences (Kitabgi 2009)
    HOMOLOGY
    Homologene
    FAMILY
  • neurotensin family
  • CATEGORY regulatory , signaling neurotransmitter
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • modulating dopaminergic neuronal activity
  • responsible for regulatory and trophic effets, including gut motility
  • may play an endocrine or paracrine role in the regulation of fat metabolism
  • uses PKC-dependent pathways to modulate GSK3A, GSK3B, which may play a role in the NTS regulation of intestinal cell growth (Wang 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • functions as both a neurotransmitter and a hormone through the activation of the neurotensin receptor NTSR1
  • cell & other
    REGULATION
    Other regulation of NTS expression by NR2F2, which may have important consequences for lipid metabolism
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    through two pathways during inflammatory bowel disease-related oncogenesis: one triggered by NTS overexpression, and a second associated with an activation of the APC/beta-catenin pathway (Bossard 2007)
    tumoral     --other  
    expressed in the ductal and invasive components of invasive ductal breast carcinomas (IDCs)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS