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FLASH GENE

Symbol

NTNG1

contributors: mct/npt - updated : 04-12-2019

HGNC name	netrin G1
HGNC id	23319

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p13.3      Physical location : 107.682.628 - 108.024.471
Synonym name	related to chicken netrin 2, precursor
	laminet 1
	axon guidance molecule
	netrin G1f
Synonym symbol(s)	KIAA0976, Lmnt1, YLSR571

DNA

TYPE	functioning gene
STRUCTURE	341.85 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001113226 8 splicing 3434 NP_001106697 60.4 539 major expression restricted to brain (adult and fetal) Meerabux (2005) also called G1a NM_014917 6 splicing 3015 NP_055732 - 438 - Meerabux (2005) NM_001113228 8 splicing 3257 NP_001106699 53.8 480 major expression restricted to brain (adult and fetal) Meerabux (2005) also called G1d variant e (G1e) - splicing 265 isoform e - - major expression restricted to brain (adult and fetal) Meerabux (2005) variant l (G1l) - splicing 172 isoform l - 57 - Meerabux (2005) variant m (G1m) - splicing 660 isoform m - - only adult brain Meerabux (2005) variant n (G1n) - splicing 450 isoform n - - only adult brain Meerabux (2005) variant o (G1o) - splicing 400 isoform o - - only in adult brain Meerabux (2005)

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain diencephalon thalamus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, fetal

Text	CNS midbrain and mindbrain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one laminin EGF-like domain
	one laminin N-terminal domain

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

UNC6/netrin family

CATEGORY

signaling

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	playing a role in nervous system development
	promotes neurite outgrowth of both axons and dendrites
	implicated in the pathophysiology of schizophrenia and bipolar disorder (Eastwood 2008)
	axon-guidance-pathway molecules are involved in connectivity and repair throughout life (beyond guiding brain wiring during fetal development) (Lin 2009)
	NTGN1/LRRC4C, NTGN2/LRRC4 interactions differentially control synaptic plasticity in distinct circuits via retrograde signaling mechanisms
	pre-synaptic NTNG1 and NTNG2 diversify the complexity of vertebrate behaviors and differentially regulate post-synaptic properties

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

text	nervous system development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

LRRC4C interact with the presynaptic ligands netrin-G1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   translocation     and deleted in Rett syndrome with t(1;7)(p22;q32)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS