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FLASH GENE
Symbol NTNG1 contributors: mct/npt - updated : 28-05-2010
HGNC name netrin G1
HGNC id 23319
Location 1p13.3      Physical location : 107.682.628 - 108.024.471
Synonym name
  • related to chicken netrin 2, precursor
  • laminet 1
  • axon guidance molecule
  • netrin G1f
  • Synonym symbol(s) KIAA0976, Lmnt1, YLSR571
    DNA
    TYPE functioning gene
    STRUCTURE 341.85 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391064 1 hypothetical gene supported by AK001388 LOC126987 1p13.3 similar to tight junction protein 3 (zona occludens 3) PRMT6 1p13.3 similar to tight junction protein 3 (zona occludens 3) NTNG1 1p13.3 netrin G1 LOC360165  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa, pseudogene VAV3 1p22.3-p11 vav 3 oncogene DKFZp586G0123 1p13.3 calcium-binding transporter FLJ32833 1p13.3 hypothetical protein FLJ32833 LOC388657 1 similar to calcium-binding transporter LOC343141 1p13.3 similar to calcium-binding transporter LOC388658 1 similar to hypothetical protein MGC8902 LOC388659 1 similar to RIKEN cDNA C230093N12 FLJ30525 1p13.3 hypothetical protein FLJ30525 FLJ10330 1p13.3 hypothetical protein FLJ10330 FLJ35838 1p13.3 hypothetical protein FLJ35838 STXBP3 1p21-p13.3 syntaxin binding protein 3 MGC26989 1p13.3 hypothetical protein MGC26989 LGN MCLC 1p13.2 hypothetical protein MGC26989 KIAA0893 1p13.3 hypothetical protein MGC26989 NDUFB3P1 1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 1 AD-020 1p13.3 protein x 013 LOC391065 1 similar to poly(rC) binding protein 1; heterogenous nuclear ribonucleoprotein X; poly(rC)-binding protein 1; alpha-CP1; nucleic acid binding protein sub 2.3; heterogenous nuclear ribonucleoprotein E1 LOC127003 1p13.3 similar to CG5435-PA KIAA1324 1p13.2 maba1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 splicing 3434 60.4 539 major expression restricted to brain (adult and fetal) Meerabux (2005)
    also called G1a
    6 splicing 3015 - 438 - Meerabux (2005)
    8 splicing 3257 53.8 480 major expression restricted to brain (adult and fetal) Meerabux (2005)
    also called G1d
    - splicing 265 - - major expression restricted to brain (adult and fetal) Meerabux (2005)
    - splicing 172 - 57 - Meerabux (2005)
    - splicing 660 - - only adult brain Meerabux (2005)
    - splicing 450 - - only adult brain Meerabux (2005)
    - splicing 400 - - only in adult brain Meerabux (2005)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonthalamus  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text CNS midbrain and mindbrain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one laminin EGF-like domain
  • one laminin N-terminal domain
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • UNC6/netrin family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing a role in nervous system development
  • promotes neurite outgrowth of both axons and dendrites
  • implicated in the pathophysiology of schizophrenia and bipolar disorder (Eastwood 2008)
  • axon-guidance-pathway molecules are involved in connectivity and repair throughout life (beyond guiding brain wiring during fetal development) (Lin 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text nervous system development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   translocation    
    and deleted in Rett syndrome with t(1;7)(p22;q32)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS