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FLASH GENE
Symbol NTN4 contributors: mct/npt - updated : 15-04-2008
HGNC name netrin 4
HGNC id 13658
Location 12q22-q23      Physical location : 96.051.583 - 96.184.536
Synonym name
  • beta-netrin
  • hypothetical protein similar to mouse netrin 4
  • hepar-derived netrin-like protein
  • Synonym symbol(s) PRO3091, FLJ23180
    DNA
    TYPE functioning gene
    STRUCTURE 132.95 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3634 70.1 628 - Koch (2000)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Olfactory (smell)olfactory bulb   highly
    Reproductivefemale systemovary  highly
    Urinarybladder   highly
     kidney   highly
    Visualeyeretina  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a laminin-like domain VI
  • 3.5 laminin EGF repeats
  • a netrin C domain
  • HOMOLOGY
    interspecies homolog to murine Ntn4
    Homologene
    FAMILY
  • netrin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    intracellular,cytoplasm,organelle,lumen
    text basement membrane
    basic FUNCTION
  • acts as an antiangiogenic factor through binding to neogenin (NEO1) and recruitment of UNC5B
  • promotes neurite elongation from olfactory bulb explants and is important in neural, kidney, and vascular development
  • may improve poststroke functional recovery by enhancing blood vessel proliferation (Hoang 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • basement membrane component (present in the basement membranes of the vasculature, kidney, and ovaries)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in VEGF-stimulated endothelial cells
    constitutional       gain of function
    in the ischemic core as soon as 1 day after cerebral ischemia, with subsequent downregulation after 1 week (Hoang 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target could be a promising alternative avenue for therapeutic intervention to anti-VEGF therapies
    ANIMAL & CELL MODELS