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FLASH GENE
Symbol NTN4 contributors: mct/npt - updated : 15-04-2008
HGNC name netrin 4
HGNC id 13658
Location 12q22-q23      Physical location : 96.051.583 - 96.184.536
Synonym name
  • beta-netrin
  • hypothetical protein similar to mouse netrin 4
  • hepar-derived netrin-like protein
    • Synonym symbol(s) PRO3091, FLJ23180
    DNA
    TYPE functioning gene
    STRUCTURE 132.95 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC341444 12q22 similar to alpha NAC/1.9.2. protein LOC387873 12 LOC387873 NUDT4 12q21 nudix (nucleoside diphosphate linked moiety X)-type motif 4 UBE2N 12q21.33 ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) MRPL42 12q22 mitochondrial ribosomal protein L42 SOCS2 12q21.3-q23 suppressor of cytokine signaling 2 LOC144483 12q22 similar to Phosphoglycerate mutase 1 (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1) CRADD 12q21.33-q23.1 CASP2 and RIPK1 domain containing adaptor with death domain PLXNC1 12q23.3 plexin C1 NY-REN-58 12q22 NY-REN-58 antigen LOC387874 12 hypothetical gene supported by NM_014886 LOC283398 12q22 similar to Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial precursor (Succinyl-CoA synthetase, betaG chain) (SCS-betaG) (GTP-specific succinyl-CoA synthetase beta subunit) KIAA1145 12q22 KIAA1145 protein DAP13 12q23.1 13kDa differentiation-associated protein NR2C1 12q22 nuclear receptor subfamily 2, group C, member 1 FGD6 12q23.1 FYVE, RhoGEF and PH domain containing 6 VEZATIN 12q21.33 FYVE, RhoGEF and PH domain containing 6 LOC387875 12 LOC387875 LOC283412 12q23.1 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) METAP2 12q22 methionyl aminopeptidase 2 USP44 12q21.33 ubiquitin specific protease 44 NTN4 12q22-q23 netrin 4 SNRPF 12q21.33 small nuclear ribonucleoprotein polypeptide F FLJ40089 12q23.1 hypothetical protein FLJ40089 MGC35366 12q23.1 hypothetical protein MGC35366 HAL 12q22-q23.1 histidine ammonia-lyase LTA4H 12q22 leukotriene A4 hydrolase ELK3 12q22-q23.1 ELK3, ETS-domain protein (SRF accessory protein 2) PCTK2 12q23.1 PCTAIRE protein kinase 2 FLJ31514 12q23.1 hypothetical protein FLJ31514 FLJ44112 12q23.1 FLJ44112 protein LOC387876 12 LOC387876 LOC390352 12 similar to eukaryotic translation elongation factor 1 alpha 1; CTCL tumor antigen; translation elongation factor 1 alpha 1-like 14; prostate tumor-inducing protein 1; EF1a-like protein; glucocorticoid receptor AF-1 specific elongati NEDD1 12q22 neural precursor cell expressed, developmentally down-regulated 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3634 70.1 628 - Koch (2000)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Olfactory (smell)olfactory bulb   highly
    Reproductivefemale systemovary  highly
    Urinarybladder   highly
     kidney   highly
    Visualeyeretina  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a laminin-like domain VI
  • 3.5 laminin EGF repeats
  • a netrin C domain
    • HOMOLOGY
    interspecies homolog to murine Ntn4
    Homologene
    FAMILY
  • netrin family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    intracellular,cytoplasm,organelle,lumen
    text basement membrane
    basic FUNCTION
  • acts as an antiangiogenic factor through binding to neogenin (NEO1) and recruitment of UNC5B
  • promotes neurite elongation from olfactory bulb explants and is important in neural, kidney, and vascular development
  • may improve poststroke functional recovery by enhancing blood vessel proliferation (Hoang 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • basement membrane component (present in the basement membranes of the vasculature, kidney, and ovaries)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in VEGF-stimulated endothelial cells
    constitutional       gain of function
    in the ischemic core as soon as 1 day after cerebral ischemia, with subsequent downregulation after 1 week (Hoang 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target could be a promising alternative avenue for therapeutic intervention to anti-VEGF therapies
    ANIMAL & CELL MODELS