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FLASH GENE

Symbol

NTM

contributors: mct - updated : 23-06-2020

HGNC name	neurotrimin
HGNC id	17941

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q25      Physical location : 131.240.370 - 132.206.715
Synonym name	IgLON family member 2
Synonym symbol(s)	MGC60329, HNT, CEPU-1, IGLON2, NTRI

DNA

TYPE	functioning gene
SPECIAL FEATURE	gene in gene
STRUCTURE	966.51 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001048209 8 - 2903 NP_001041674 - 344 - 2015 25819087 NM_016522 7 - 2857 NP_057606 37 344 - 2015 25819087 NM_001352006 10 - 3056 NP_001338935 - 346 - 2015 25819087 NM_001352007 9 - 3023 NM_001352001 10 - 2972 NP_001338930 - 367 - 2015 25819087 NM_001352003 9 - 2939 NP_001338932 - 356 - 2015 25819087 NP_001338932 9 - 2936 NP_001338934 - 355 - 2015 25819087 NM_001386964 9 - 2773 NP_001373893 - - - 2015 25819087 NM_001352004 8 - 3411 NP_001338933 - - - 2015 25819087 NM_001352002 9 - 3444 NP_001338931 - 367 - 2015 25819087 NM_001352005 9 - 2936 NP_001338934 - 355 - 2015 25819087 NM_001352008 8 - 3060 NP_001338937 - 325 - 2015 25819087

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain forebrain cerebral cortex     Homo sapiens   brain hindbrain pons   highly Homo sapiens   brain hindbrain cerebellum       spinal cord       highly Homo sapiens Olfactory (smell) olfactory bulb         Visual eye retina

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens Nervous Purkinje cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal signal sequence
	three Ig-like domains
	six cysteines that likely form intradomain disulfide bonds
	a C-terminal GPI attachment site

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murine Ntm

Homologene

FAMILY	immunoglobulin C-2 type family
	plasticity-associated IgLON family neural adhesion molecules
	IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules

CATEGORY

adhesion , immunity/defense

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm

basic FUNCTION	may be promoting neurite outgrowth and adhesion via a homophilic mechanism
	LSAMP and NTM promote adhesion and neurite outgrowth via a homophilic mechanism, suggesting that these proteins promote the formation of specific neuronal circuits by homophilic interactions
	IgLON cell adhesion molecules (CAMs) participate in regulating synapse formation in hippocampal neurons
	role for all IgLON family members in promoting neurite extension from cortical neurons
	NTM exerts an inhibitory impact on neurite outgrowth
	NTM is linked to intelligence and cognitive function

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	role for neurotrimin in mediating estrogen-induced sympathetic pruning in some peripheral targets
	interplay between LSAMP and NTM in regulating tissue homeostasis: the impact of NTM on cellular proliferation was dependent on LSAMP, and LSAMP appeared to be a positive regulator of apoptosis in the presence of NTM
	IgLONs maintain an extended conformation and that their dimerization occurs through the first Ig domain of each monomer and is Ca2+ independent

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   increased selectively in the myometrium during the high-estrogen phase of the estrous cycle

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	NTM is a novel biomarker in heart failure
Therapy target

ANIMAL & CELL MODELS