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FLASH GENE
Symbol NTHL1 contributors: - updated : 22-03-2006
HGNC name nth endonuclease III-like 1 (E. coli)
HGNC id 8028
Location 16p13.3-p13.2      Physical location : 2.089.815 - 2.097.867
Synonym symbol(s) NTH1, OCTS3
EC.number 4.2.99.18
DNA
TYPE functioning gene
STRUCTURE 7.00 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
cytosine-phosphate-guanine/HTF
Binding site   transcription factor
text structure multiple initiation sites
MAPPING cloned Y linked N status provisional
Physical map
NME3 16q13 non-metastatic cells 3, protein expressed in MRPS34 16p13.3 mitochondrial ribosomal protein S34 LOC390668 16 similar to hypothetical protein 6820428D13 SSB3 16p13.3 SPRY domain-containing SOCS box protein SSB-3 NUBP2 16p13.3 nucleotide binding protein 2 (MinD homolog, E. coli) IGFALS 16p13.3 insulin-like growth factor binding protein, acid labile subunit HAGH 16p13.3 hydroxyacyl glutathione hydrolase DKFZP566J2046 16p13.3 hypothetical protein DKFZp566J2046 MGC35212 16p13.3 hypothetical protein MGC35212 LOC342460 16p13.3 similar to c439A6.1 (novel protein similar to heparan sulfate (glucosamine) 3-O-sulfotransferases) SEPX1 16p13.3 selenoprotein X, 1 RPL3L 16p13.3 ribosomal protein L3-like NDUFB10 16p13.3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa RPS2 16p13.3 ribosomal protein S2 RNF151 16p13.3 ring finger protein 151 TBL3 16p13.3 transducin (beta)-like 3 NOXO1 16p13.3 NADPH oxidase organizer 1 GFER 16p13.3-p13.12 growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae) SYNGR3 16p13 synaptogyrin 3 LOC90850 16p13.3 hypothetical protein LOC90850 SLC9A3R2 16p13.3 solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 2 NTHL1 16p13.3p13.2 nth endonuclease III-like 1 (E. coli) TSC2 16p13.3 tuberous sclerosis 2 PKD1 16p13.3 polycystic kidney disease 1 (autosomal dominant) RFWD1 16p13.3 ring finger and WD repeat domain 1 RAB26 16p13.3 RAB26, member RAS oncogene family CASKIN1 16p13.11 CASK interacting protein 1 GBL 16p13.3 G protein beta subunit-like MGC21830 16p13.3 hypothetical protein MGC21830 LOC388203 16 LOC388203 LOC283871 16p13.3 hypothetical protein LOC283871 E4F1 16p13.3 E4F transcription factor 1 DNASE1L2 16p13.3 deoxyribonuclease I-like 2 DCI 16p13.3 dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenzyme A isomerase) RNPS1 16p13.3 RNA binding protein S1, serine-rich domain
regionally located adjacent tp TSC2 in 5' to 5' orientation
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinelarge intestinecolon highly
 stomach   highly
Reproductivefemale systemovary  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
secondary structure helix hairpin helix and glycine/proline-rich loop, a nuclear localization signal (NLS)
HOMOLOGY
interspecies homolog to E.coli nth endonuclease III-like 1
intraspecies homolog to HhH-GPD family of BER pathway
Homologene
FAMILY NTH/MUTY family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
basic FUNCTION
  • having both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity
  • involved in the excision of damaged pyrimidines, purines (8 oxoguanine) end
  • bifunctional enzyme with DNA glycosylase and AP lyase activities
  • CELLULAR PROCESS nucleotide, repair, base excision repair
    PHYSIOLOGICAL PROCESS
    text base excision repair
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    nucleotide
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with TP53 and proliferating cell nuclear antigen
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS