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FLASH GENE
Symbol NTF3 contributors: mct - updated : 05-02-2016
HGNC name neurotrophin 3
HGNC id 8023
Location 12p13.31      Physical location : 5.541.279 - 5.604.463
Synonym symbol(s) NT3, NGF2, HDNF, MGC129711, NGF-2, NGF-2, NT-3
DNA
TYPE functioning gene
STRUCTURE 63.19 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 splicing 1182 - 257 - 2000 10854245
  • TR1B
  • splicing exon 1A
  • 2 splicing 1349 - 270 - 2000 10854245
  • TR1A
  • splicing exon 1B
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumearinner    Homo sapiens
    Reproductivefemale systemovary   
     male systemprostate   
    Skin/Tegumentskinscalp   
     skin appendageshairfollicle  
    Visualeyeanterior segmentiris  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningepidermis  
    Muscularsmoothmuscularis mucosa (tractus digestif)   Homo sapiensFetal
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Hearing / Equilibriumhair cell receptor Homo sapiens
    VisualMuller cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    preprosequence of 138 AA giving a mature region, 119AA after cleavage
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY nerve growth factor family (NT family of trophic factors)
    CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • maintenance of the adult nervous system, development of neurons in embryo
  • playing an essential role for nervous system development
  • functional interchangeability between the pro-peptides of NGF and NTF3 with respect to their role in assisting oxidative folding of the mature part
  • NTF3 and BDNF exert a profound effect on the types of neurotransmitter receptors expressed on postnatal spiral ganglion neurons, results that may have important implications for neural development and plasticity
  • has a role in the developmental mechanism that eliminates redundant synapses though it cannot modulate synaptic transmission locally as the NMJ matures
  • proNTF3 and proBDNF may play important roles in the response to noise-induced injuries or ototoxic damage via the Sortilin:NGFR death-signalling complex
  • has a distinctive role, not mimicked by BDNF, in promoting spiral ganglion neurons axon growth in the organ of Corti and synaptogenesis on inner hair cells
  • NGF and NTF3 collaborate to support development of sympathetic neurons, and NGF but not NTF3 supports retrograde survival of sympathetic neurons
  • motoneuron is a functional source of NTF3 and motoneuron-derived NTF3 is an essential pre-target neurotrophin for survival and axonal projection of sensory neurons
  • NTF3 can synergize with IGFBP2 to promote hematopoietic cell expansion
  • promoted differentiation of neural stem cells (NSCs) into cholinergic neurons and enhanced neuronal cell survival
  • role for gastrointestinal (GI) NTF3 in short-term controls of feeding, most likely involving effects on development of vagal GI afferents that regulate satiation
  • displays a non-canonical cell guidance signaling function for cephalic neural crest cells
  • in the cochlar nucleus, NTF3 had a strong impact on enhancement of neuronal survival, whereas BDNF stimulated neuronal survival and axonal outgrowth
  • NTF3 and BDNF are critical for sensory neuron survival and establishment of neuronal projections to sensory epithelia in the embryonic inner ear
  • regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component component of a heterodimer with BDNF
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for NTRK3 (TRKC)
  • interacting with SP4
  • NTF3 mRNA interacted with FMR1 in wild type astrocytes
  • NTRK3 is a dependence receptor, and, as such, it triggers apoptosis in the absence of its ligand, NTF3
  • NTF3 acts downstream of ZEB2 in cortical postmitotic neurons to control progenitor cell fate through feedback signaling
  • cell & other
    REGULATION
    repressed by SP4 (direct role for SP4 as a repressor of NTF3 expression)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in brain, likely to contribute to autistic pathology not only by affecting brain axonal targeting and synapse formation but also by further exacerbating oxidative stress and possibly contributing to Purkinje cell abnormalities
    constitutional     --over  
    elevated serum levels of NGF, NTF3, and NTF4 , in patients with mastocytosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurosensorialear 
    Transplantation of neurotrophin over-expressing Schwann cells into the cochlea may provide an alternative means of delivering neurotrophic factors to the deaf cochlea for therapeutic purposes (PMID: 18304740)
    neurosensorialvisualretina
    modulation of the neuroprotective action of mature NTF3 and pro-apoptotic pro-NTF3/NGFR signaling may represent a novel pharmacological strategy for photoreceptor protection in retinal disease
    ANIMAL & CELL MODELS
  • muscles of adult Ntf3-deficient animals were weaker than those of wild-type animals to both nerve and direct muscle stimulation
  • excessive astrocyte-derived neurotrophin-3 contributes to the abnormal neuronal dendritic development in a mouse model of fragile X syndrome