Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

NTF3

contributors: mct - updated : 05-02-2018

HGNC name	neurotrophin 3
HGNC id	8023

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12p13.31      Physical location : 5.541.279 - 5.604.463
Synonym symbol(s)	NT3, NGF2, HDNF, MGC129711, NGF-2, NGF-2, NT-3

DNA

TYPE	functioning gene
STRUCTURE	63.19 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002527 2 splicing 1182 - 257 - 2000 10854245 TR1B splicing exon 1A NM_001102654 2 splicing 1349 - 270 - 2000 10854245 TR1A splicing exon 1B

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Hearing/Equilibrium ear inner       Homo sapiens Reproductive female system ovary         male system prostate       Skin/Tegument skin scalp         skin appendages hair follicle     Visual eye anterior segment iris

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining epidermis     Muscular smooth muscularis mucosa (tractus digestif)     Homo sapiens Fetal

cells

System Cell Pubmed Species Stage Rna symbol Hearing / Equilibrium hair cell receptor Homo sapiens Visual Muller cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

preprosequence of 138 AA giving a mature region, 119AA after cleavage

mono polymer

heteromer , dimer

HOMOLOGY

Homologene

FAMILY

nerve growth factor family (NT family of trophic factors)

CATEGORY

signaling growth factor

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic,vesicle

basic FUNCTION	maintenance of the adult nervous system, development of neurons in embryo
	playing an essential role for nervous system development
	functional interchangeability between the pro-peptides of NGF and NTF3 with respect to their role in assisting oxidative folding of the mature part
	NTF3 and BDNF exert a profound effect on the types of neurotransmitter receptors expressed on postnatal spiral ganglion neurons, results that may have important implications for neural development and plasticity
	has a role in the developmental mechanism that eliminates redundant synapses though it cannot modulate synaptic transmission locally as the NMJ matures
	proNTF3 and proBDNF may play important roles in the response to noise-induced injuries or ototoxic damage via the Sortilin:NGFR death-signalling complex
	has a distinctive role, not mimicked by BDNF, in promoting spiral ganglion neurons axon growth in the organ of Corti and synaptogenesis on inner hair cells
	NGF and NTF3 collaborate to support development of sympathetic neurons, and NGF but not NTF3 supports retrograde survival of sympathetic neurons
	motoneuron is a functional source of NTF3 and motoneuron-derived NTF3 is an essential pre-target neurotrophin for survival and axonal projection of sensory neurons
	NTF3 can synergize with IGFBP2 to promote hematopoietic cell expansion
	promoted differentiation of neural stem cells (NSCs) into cholinergic neurons and enhanced neuronal cell survival
	role for gastrointestinal (GI) NTF3 in short-term controls of feeding, most likely involving effects on development of vagal GI afferents that regulate satiation
	displays a non-canonical cell guidance signaling function for cephalic neural crest cells
	in the cochlar nucleus, NTF3 had a strong impact on enhancement of neuronal survival, whereas BDNF stimulated neuronal survival and axonal outgrowth
	NTF3 and BDNF are critical for sensory neuron survival and establishment of neuronal projections to sensory epithelia in the embryonic inner ear
	regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

component of a heterodimer with BDNF

INTERACTION

DNA

RNA

small molecule

protein	ligand for NTRK3 (TRKC)
	interacting with SP4
	NTF3 mRNA interacted with FMR1 in wild type astrocytes
	NTRK3 is a dependence receptor, and, as such, it triggers apoptosis in the absence of its ligand, NTF3
	NTF3 acts downstream of ZEB2 in cortical postmitotic neurons to control progenitor cell fate through feedback signaling
	POU3F2 binds to the NTF3 promoter during neuronal differentiation

cell & other

REGULATION

repressed by

SP4 (direct role for SP4 as a repressor of NTF3 expression)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in brain, likely to contribute to autistic pathology not only by affecting brain axonal targeting and synapse formation but also by further exacerbating oxidative stress and possibly contributing to Purkinje cell abnormalities constitutional     --over   elevated serum levels of NGF, NTF3, and NTF4 , in patients with mastocytosis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurosensorial ear   Transplantation of neurotrophin over-expressing Schwann cells into the cochlea may provide an alternative means of delivering neurotrophic factors to the deaf cochlea for therapeutic purposes (PMID: 18304740) neurosensorial visual retina modulation of the neuroprotective action of mature NTF3 and pro-apoptotic pro-NTF3/NGFR signaling may represent a novel pharmacological strategy for photoreceptor protection in retinal disease

ANIMAL & CELL MODELS

	muscles of adult Ntf3-deficient animals were weaker than those of wild-type animals to both nerve and direct muscle stimulation
	excessive astrocyte-derived neurotrophin-3 contributes to the abnormal neuronal dendritic development in a mouse model of fragile X syndrome