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FLASH GENE
Symbol NT5M contributors: npt/ - updated : 07-04-2006
HGNC name 5',3'-nucleotidase, mitochondrial
HGNC id 15769
Location 17p11.2      Physical location : 17.206.679 - 17.250.975
Synonym name
  • 5(3')-deoxyribonucleotidase (dNT-2),mitochondrial specific for thymise and urail deoxyribonucleotides
  • deoxy-5'-nucleotidase 2
  • Synonym symbol(s) DNT2, mdN
    EC.number 3.1.3.5
    DNA
    TYPE functioning gene
    STRUCTURE 44.30 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    ZNF287 17p11.2 zinc finger protein 287 LOC284045 17p11.2 hypothetical gene supported by NM_006275; BC006832; U30828; U30829; U30883 KIAA1349 17p11.2 KIAA1349 protein LOC390766 17 similar to Ribonuclease H1 (RNase H1) (Ribonuclease H type II) LOC147226 17p11.2 similar to yeast Upf3, variant A pseudogene LOC252841 17p11.2 signal recognition particle 68kD pseudogene LOC266619 17p11.2 nitric oxide synthase 2A (inducible, hepatocytes) pseudogene LOC353194 17p11.2 keratin pseudogene LOC388342 17 similar to Keratin, type I cytoskeletal 16 (Cytokeratin 16) (K16) (CK 16) LOC388343 17 similar to Keratin, type I cytoskeletal 14 (Cytokeratin 14) (K14) (CK 14) LOC147228 17p11.2 keratin pseudogene LOC339186 17p11.2 keratin pseudogene CLPSMCR 17p11.2 coactosin-like, Smith Magenis syndrome chromosome region LOC390768 17 similar to FLJ00050 protein LOC96597 17p11.2 hypothetical protein LOC96597 TNFRSF13B 17p11.2 tumor necrosis factor receptor superfamily, member 13B M-RIP 17p11.2 myosin phosphatase-Rho interacting protein LOC201164 17p11.2 similar to CG12314 gene product BHD MGC13008 17p11.2 hypothetical protein MGC13008 LOC390769 17 similar to actin 3 - fruit fly (Drosophila melanogaster) (fragments) COPS3 17p11.2 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis) NT5M 17p11.2 5',3'-nucleotidase, mitochondrial LOC388344 17 similar to ribosomal protein L13; 60S ribosomal protein L13; breast basic conserved protein 1 FLJ10193 RASD1 17p11.2 RAS, dexamethasone-induced 1 PEMT 17p11.2 phosphatidylethanolamine N-methyltransferase FLJ23022 17p11.2 hypothetical protein FLJ23022 RAI1 17p11.2 retinoic acid induced 1 SMCR5 17p11.2 Smith-Magenis syndrome chromosome region, candidate 5 SREBF1 17p11.2 sterol regulatory element binding transcription factor 1 TOM1L2 17p11.2 target of myb1-like 2 (chicken) DKFZP586M1120 17p11.2 hypothetical protein DKFZp586M1120 ATPAF2 17p11.2 ATP synthase mitochondrial F1 complex assembly factor 2 MGC3048 17p11.2 hypothetical protein MGC3048
    regionally located within the Smith Magenis critical region SMCR, 22kb downstream of COPS3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1633 - 228 - Rampazzo (2000)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas   lowly
    Nervousbrain    
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • mitochondrial leader peptide
  • HOMOLOGY
    interspecies homolog to murine Nt5c
    intraspecies homolog to DNT1
    Homologene
    FAMILY
  • 5'(3')-deoxyribonucleotidase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • potential protector of mt DNA from over production of dTTP
  • CELLULAR PROCESS nucleotide
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic , purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS