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FLASH GENE
Symbol NT5M contributors: npt/ - updated : 07-04-2006
HGNC name 5',3'-nucleotidase, mitochondrial
HGNC id 15769
Location 17p11.2      Physical location : 17.206.679 - 17.250.975
Synonym name
  • 5(3')-deoxyribonucleotidase (dNT-2),mitochondrial specific for thymise and urail deoxyribonucleotides
  • deoxy-5'-nucleotidase 2
    • Synonym symbol(s) DNT2, mdN
    EC.number 3.1.3.5
    DNA
    TYPE functioning gene
    STRUCTURE 44.30 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    regionally located within the Smith Magenis critical region SMCR, 22kb downstream of COPS3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1633 - 228 - Rampazzo (2000)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas   lowly
    Nervousbrain    
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • mitochondrial leader peptide
    • HOMOLOGY
    interspecies homolog to murine Nt5c
    intraspecies homolog to DNT1
    Homologene
    FAMILY
  • 5'(3')-deoxyribonucleotidase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • potential protector of mt DNA from over production of dTTP
    • CELLULAR PROCESS nucleotide
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic , purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS