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FLASH GENE
Symbol NT5E contributors: mct/shn - updated : 12-06-2013
HGNC name 5'-nucleotidase, ecto (CD73)
HGNC id 8021
Location 6q14.3      Physical location : 86.159.301 - 86.205.496
Synonym name
  • antigen CD73,identified by antibodies 1E9.8,7G2.2.11,AD2
  • 5' nucleotidase (CD73)
  • 5' nucleotidase, ecto precursor
  • 5-prime-ribonucleotide phosphohydrolase
  • Ecto-5-prime-nucleotidase
  • nucleotidase ecto-5-prime
  • Synonym symbol(s) CD73, NT5, P5N, E5NT, NT, NTE, eN, eNT, RP11-321N4.1
    EC.number 3.1.3.5
    DNA
    TYPE functioning gene
    STRUCTURE 45.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D6S1601 - D6S1652 - CD73 - D5S1482 - D6S1004 - qter
    Physical map
    KIAA1117 6q15 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, pseudogene PGM3 6q14.1-q15 phosphoglucomutase 3 RWDD2 6q15 RWD domain containing 2 ME1 6q12 malic enzyme 1, NADP(+)-dependent, cytosolic C6orf158 6q15 chromosome 6 open reading frame 158 SNAP91 6q13 synaptosomal-associated protein, 91kDa homolog (mouse) C6orf159 6q15 chromosome 6 open reading frame 159 NCB5OR 6pter-q22.33 NADPH cytochrome B5 oxidoreductase C6orf117 6q14.3 chromosome 6 open reading frame 117 C6orf84 6pter-q16.1 chromosome 6 open reading frame 84 LOC346033 6q15 similar to SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1 TBX18 6p14-q15 T-box 18 LOC391946 6 similar to ribosomal protein L31 LOC391947 6 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC391948 6 similar to Translationally controlled tumor protein (TCTP) (p23) (Histamine-releasing factor) (HRF) NT5E 6q14-q15 5'-nucleotidase, ecto (CD73) SNX14 6q15 sorting nexin 14 SYNCRIP 6q14-q15 synaptotagmin binding, cytoplasmic RNA interacting protein LOC389414 6 LOC389414 LOC391949 6 similar to 60S ribosomal protein L7 LOC134686 6q15 similar to NADH-ubiquinone oxidoreductase 13 kDa-B subunit (Complex I-13Kd-B) (CI-13Kd-B) (Complex I subunit B13) HTR1E 6q14-q15 5-hydroxytryptamine (serotonin) receptor 1E CGA 6q12-q21 glycoprotein hormones, alpha polypeptide LOC391950 6 similar to Reticulocalbin 1 precursor LOC389415 6 LOC389415 ZNF292 6q15 zinc finger protein 292 GJB7 6q15 gap junction protein, beta 7 C6orf162 6q15-q16.1 chromosome 6 open reading frame 162 C6orf163 6q15 chromosome 6 open reading frame 163 C6orf165 6q15 chromosome 6 open reading frame 165 TAF13P 6q14.3-15 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, pseudogene SLC35A1 6q16.1 solute carrier family 35 (CMP-sialic acid transporter), member A1 RARSL 6q16.1 arginyl-tRNA synthetase-like ORC3L 6q14.3-16.3 origin recognition complex, subunit 3-like (yeast) C6orf166 6q15 chromosome 6 open reading frame 166
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 4087 - 574 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinethyroid   highly
    Respiratoryrespiratory tracttrachea  highly
    Skin/Tegumentskin   highly
    Urinarykidney    
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta, retina
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to Nt5e, Mus musculus
    ortholog to nt5e, Danio rerio
    ortholog to Nt5e, Rattus norvegicus
    ortholog to NT5E, Pan troglodytes
    Homologene
    FAMILY 5'-nucleotidase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • bounds by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane
  • expressed on normal and neoplastic glial plasma membranes (Ludwig et al, 1999)
  • basic FUNCTION
  • cell surface enzyme of the purine catabolic pathway that catalyzes the breakdown of AMP to adenosine
  • hydrolyzing extracellular nucleotides into membrane permeable nucleosides
  • may facilitate the adhesion, migration and invasion of human breast cancer cells through its enzyme activity of generating adenosine
  • required for the efficient entry of lymphocytes into the CNS during experimental autoimmune encephalomyelitis development
  • novel and specific receptor for tenascin C and the interaction between these proteins may influence cell adhesion and migration and also lead to decreased generation of local adenosine (Sadej 2008)
  • a signalling pathway metabolite in the immune response of lymphocytes
  • a cell surface marker of cone/rod common precursors and mature rod cells genetically localized between Nrl and Crx (Koso 2009)
  • extracellular adenosine, generated in tandem by ecto-enzymes ENTPD1 and NT5E, promotes dermal fibrogenesis
  • ENTPD1, NT5E are two ectonucleotidases that cooperate in the generation of extracellular adenosine through ATP hydrolysis, thus tilting the balance towards immunosuppressive microenvironments
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    nucleotide
    a component
  • glycoprotein constituent of membrane (Pi linked)
  • component of multiresistance machinery, the transcription of which is activated under selective pressure of the immune system (Ludwig et al, 1999)
  • INTERACTION
    DNA
    RNA
    small molecule cofactor,
    zinc
    protein
  • intracellular filamentous actin and the extracellular matrix proteins laminin and fibronectin (Ludwig et al, 1999)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in melanoma with with a highly invasive phenotype
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    dermatologyskin 
    biochemical or biological inhibitors of ENTPD1 and/or NT5E may hold promise in the treatment of dermal fibrosis in diseases such as scleroderma
    ANIMAL & CELL MODELS
  • ecto-5'-nucleotidase/CD73-deficient mice have a significantly reduced fall in stop flow pressure and superficial nephron glomerular filtration rate in response to a saturating increase of tubular perfusion flow (Castrop et al, 2004)