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FLASH GENE
Symbol NSUN4 contributors: mct - updated : 06-10-2014
HGNC name NOP2/Sun domain family, member 4
HGNC id 31802
Location 1p33      Physical location : 46.806.389 - 46.830.690
Synonym name
  • sperm head and tail associated protein
  • NOL1/NOP2/Sun domain family, member 4
  • putative methyltransferase NSUN4
  • Synonym symbol(s) SHTAP, MGC22960, RP4-603I14.2
    EC.number 2.1.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 24.30 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 4465 43.1 384 - 2009 19686095
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Digestiveintestinesmall intestine  moderately
    Reproductivefemale systembreastmammary gland moderately
     female systemplacenta  moderately
     male systemtestis  moderately
    Respiratoryrespiratory tractlarynx  predominantly
    Visualeye   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • methyltransferase superfamily
  • RsmB/NOP family
  • NOL1/NOP2/Sun domain family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • with the NSUN4-CRISP2 complex play a role in the attainment of sperm functional competence
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • NSUN4/MTERF4 complex is required to assemble the small (SSU) and large subunit (LSU) of ribosome to form a monosome
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CRISP2-binding partner (CAP (CRISP/antigen 5/pathogenesis related-1) and CRISP domains of CRISP2 were required for maximal binding to NSUN4)
  • NSUN4 binds to the C-terminus of MTERF4
  • is thus a dual function protein, which on the one hand is needed for 12S rRNA methylation and, on the other hand interacts with MTERF4 to facilitate monosome assembly
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS