basic FUNCTION
| stimulating sumoylation of SMC6 and the DNA repair protein TSNAX |
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SUMO ligase required for DNA repair with SMC5/6 complex for the prevention of DNA damage-induced apoptosis by facilitating DNA repair in cells |
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SMC5 and NSMCE2 are required for chromosome cohesion and mitotic progression |
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depletion of NSMCE2 seems to impair G1-S transition due to lowered E2F1 protein levels and CCNE/CDK2 activity |
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role for NSMCE2 in recovery from DNA damage, suggesting that loss of its function produces dwarfism through reduced tolerance of replicative stress |
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SUMO- and BLM-independent activities of NSMCE2 limit recombination and facilitate segregation |
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NSMCE2 appeared not essential for a proper DNA damage response or cell survival after DSB induction by ionizing irradiation (IR) |
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is an important small ubiquitin-related modifier (SUMO) ligase |
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despite the essential roles of NSMCE2 in somatic cells, chromatin integrity maintenance seems differentially regulated in the germline |