Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

NSMCE1

contributors: mct - updated : 07-05-2020

HGNC name	non-SMC element 1 homolog (S. cerevisiae)
HGNC id	29897

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16p12.1      Physical location : 27.236.314 - 27.280.113
Synonym symbol(s)	NSE1
EC.number	2.3.2.27

DNA

TYPE	functioning gene
STRUCTURE	43.78 kb     7 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_145080 8 - 1042 NP_659547 27 266 - 2008 18667531

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly   vessel       moderately Lymphoid/Immune thymus       highly Reproductive male system prostate     highly Respiratory respiratory tract larynx     moderately

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

C-terminal RING finger typical of E3 ubiquitin ligases , a RING-like motif that often confers ubiquitin E3 ligase activity

mono polymer

complex

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm

basic FUNCTION	involved in protein ubiquitination
	depletion of NSMCE1 and NSMCE4a conferred sensitivity to methyl methanesulfonate (MMS) but not to several other DNA-damaging agents, as measured by colony-forming activity
	mainly involved in maintenance of genome integrity, DNA damage response, and DNA repair
	potential molecular and cellular functions of NSMCE1 in hippocampal neuronal cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

intracellular signaling cascade

a component	ubiquitin ligase complex
	NSMCE1, NSMCE3, EID3 form a tight sub-complex of the large SMC5-6 protein complex

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein	NSMCE1 NH-RING promotes the localization or retention of NSMCE4A and thus, likely the SMC5-SMC6 holocomplex, at DNA damage sites upon genotoxic stress
	MAGEF1-NSMCE1 E3 ubiquitin ligase regulates the cytosolic iron-sulfur (Fe-S) cluster assembly (CIA) pathway through ubiquitination and degradation of the CIA-targeting protein MMS19
	MAGEF1 in conjunction with NSMCE1 promotes MMS19 ubiquitination
	PJA1 attenuates the interaction of NSMCE4A with NSMCE1

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS