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FLASH GENE
Symbol NSMCE1 contributors: mct - updated : 07-05-2020
HGNC name non-SMC element 1 homolog (S. cerevisiae)
HGNC id 29897
Location 16p12.1      Physical location : 27.236.314 - 27.280.113
Synonym symbol(s) NSE1
EC.number 2.3.2.27
DNA
TYPE functioning gene
STRUCTURE 43.78 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1042 27 266 - 2008 18667531
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
 vessel   moderately
Lymphoid/Immunethymus   highly
Reproductivemale systemprostate  highly
Respiratoryrespiratory tractlarynx  moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal RING finger typical of E3 ubiquitin ligases , a RING-like motif that often confers ubiquitin E3 ligase activity
  • mono polymer complex
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in protein ubiquitination
  • depletion of NSMCE1 and NSMCE4a conferred sensitivity to methyl methanesulfonate (MMS) but not to several other DNA-damaging agents, as measured by colony-forming activity
  • mainly involved in maintenance of genome integrity, DNA damage response, and DNA repair
  • potential molecular and cellular functions of NSMCE1 in hippocampal neuronal cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    intracellular signaling cascade
    a component
  • ubiquitin ligase complex
  • NSMCE1, NSMCE3, EID3 form a tight sub-complex of the large SMC5-6 protein complex
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • NSMCE1 NH-RING promotes the localization or retention of NSMCE4A and thus, likely the SMC5-SMC6 holocomplex, at DNA damage sites upon genotoxic stress
  • MAGEF1-NSMCE1 E3 ubiquitin ligase regulates the cytosolic iron-sulfur (Fe-S) cluster assembly (CIA) pathway through ubiquitination and degradation of the CIA-targeting protein MMS19
  • MAGEF1 in conjunction with NSMCE1 promotes MMS19 ubiquitination
  • PJA1 attenuates the interaction of NSMCE4A with NSMCE1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS