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FLASH GENE
Symbol NSL1 contributors: mct - updated : 18-05-2011
HGNC name NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)
HGNC id 24548
Location 1q41      Physical location : 212.899.495 - 212.965.139
Synonym symbol(s) DC8, C1orf48, DKFZp566O1646, MIS14
DNA
TYPE functioning gene
STRUCTURE 65.64 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 13148 - 181 - 2010 20231385
7 - 13233 - 213 - 2010 20231385
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PXVXL motif and a chromoshadow domain
  • a tripartite-binding domain for CBX5 and two other kinetochore proteins, DSN1 and CASC5
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in inner centromere architecture through a direct interaction with CBX5 (heterochromatin protein 1), mediated via the PXVXL motif and the chromoshadow domain
  • cornerstone for the assembly of the inner centromere and kinetochore
  • NSL1 subunit is a scaffold supporting interactions of the MIS12 complex with the NDC80 and CASC5 complexes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of the heterotetrameric MIS12 complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • mitotic function of NSL1 and CBX5 requires their functional association at interphase
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS