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FLASH GENE
Symbol NSFL1C contributors: mct - updated : 14-03-2015
HGNC name NSFL1 (p97) cofactor (p47)
HGNC id 15912
Location 20p13      Physical location : 1.422.812 - 1.448.417
Synonym name
  • SHP1 homolog
  • UBX domain-containing protein 2C
  • Synonym symbol(s) P47, dJ776F14.1, UBX1, UBXD10, UBXN2C
    DNA
    TYPE functioning gene
    STRUCTURE 25.53 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status
    Physical map
    C20orf140 20p13 chromosome 20 open reading frame 140 CSNK2A1 20p13 casein kinase 2, alpha 1 polypeptide TCF15 20p13 transcription factor 15 (basic helix-loop-helix) C20orf139 20p13 chromosome 20 open reading frame 139 LOC391226 20 similar to dJ850E9.1 (novel C2H2 type zinc finger protein similar to Drosophila Scratch (Scrt), Slug and Xenopus Snail) C20orf54 20p13 chromosome 20 open reading frame 54 RPS10L 20p13 ribosomal protein S10-like C20orf55 20p13 chromosome 20 open reading frame 55 ANGPT4 20p13 angiopoietin 4 LOC343637 20p13 similar to dJ824F16.3 (novel protein similar to mouse thrombospondin type 1 domain protein R-spondin) PSMF1 20p13-p12.2 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) ACTGP3 20p13 actin, gamma pseudogene 3 C20orf46 20p13 chromosome 20 open reading frame 46 SNPH 20p13 syntaphilin SDCBP2 20p13 syndecan binding protein (syntenin) 2 FLJ20802 20p13 hypothetical protein FLJ20802 FKBP1A 20p13 FK506 binding protein 1A, 12kDa NSFL1C 20p13 NSFL1 (p97) cofactor (p47) PTPNS1L3 20p12.2-13 protein tyrosine phosphatase, non-receptor type substrate 1-like 3 PTPNS1L2 20p13 protein tyrosine phosphatase, non-receptor type substrate 1-like 2 SIRPB1 20p13 signal-regulatory protein beta 1 SIRPB2 20p13 signal-regulatory protein beta 2 LOC391227 20 similar to Signal-regulatory protein beta-2 precursor (SIRP-beta-2) (SIRP-b2) LOC388779 20 LOC388779 PTPNS1 20p13 protein tyrosine phosphatase, non-receptor type substrate 1 PDYN 20p13 prodynorphin RPL7P2 20p13 ribosomal protein L7 pseudogene 2 STK35 20 serine/threonine kinase 35 LOC388780 20 LOC388780 TGM3 20p13 transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase) TGM6 20p13 transglutaminase y
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 3568 40 368 - 1998 9824302
    8 - 3475 - 339 - 1998 9824302
    10 - 3574 - 372 - 1998 9824302
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineplacenta    
    Lymphoid/Immunethymus    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    one UBX domain
    HOMOLOGY
    interspecies homolog to murine LOC381642
    homolog to rattus p47
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,intermed filament
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • VCIP1 and NSFL1C are shown to function in Golgi
  • and ER assembly
  • localization and phosphorylation of NSFL1C are important for Golgi disassembly-assembly during the cell cycle
  • essential factor for Golgi membrane fusion
  • is critical for negatively regulating stimulation-induced IKK activation in a manner that is mechanistically distinct from the previously characterized negative regulators, such as TNFAIP3 and CYLD
  • UBXN2B/NSFL1C adaptors of VCP regulate mitosis by limiting the centrosomal recruitment of AURKA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • VCP-binding protein, functions in Golgi membrane fusion together with VCP and VCPIP1, another VCP-binding protein
  • associates with the IKBKG subunit of the IKB kinase (IKK) complex upon TNF or IL1 stimulation, and inhibits IKK activation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS