basic FUNCTION
| acting as a putative chromatin modulator |
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may regulate genes which could be functionally linked to cellular signaling pathways such as cell growth, cell cycle, cell motility, transcription, and apoptosis |
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a candidate tumor suppressor |
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WHSC1L1 as well as JMJD6 is recruited to regulated genes in a BRD4-dependent manner |
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regulates transcription by modifying the chromatin microenvironment at BRD4 target genes |
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GLTSCR1, WHSC1L1, and JMJD6 impart a CDK9-independent transcriptional activation function on BRD4 |
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critical in maintaining the chromatin integrity |
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NSD3 is the first protein methyltransferase essential for neural crest gene expression during specification and NSD3-related methyltransferase activity independently regulates migration. |
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NSD1, NSD2 and NSD3, have crucial roles in chromatin regulation and are implicated in oncogenesis |
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is one of six H3K36-specific lysine methyltransferases in metazoans, and the methylation of H3K36 is associated with active transcription (PMID ( |