motifs/domains
| three C5HCH and four plant homeodomains (PHDs), which are implicated in chromatin regulation and are zinc finger like motifs characterized by cysteine and histidine residues |
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two PWWP (proline-2 tryptophan-proline)domains (one in N-terminus) |
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two nuclear receptor-interaction domains (NID) |
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ten putative nuclear localization signals |
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a single FSXXLXXL motif facilitates its interactions with the NR2E/F subfamily |
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several motifs, lysine methyltransferase SET domain and four zinc-binding PHD fingers, in the C-terminal half that are undoubtedly critical for its proposed functions in signaling and chromatin regulation |
basic FUNCTION
| SET-domain histone lysine methyltransferase, maybe acting as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator |
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may be involved in imprinting of the chromosome 11p15 region |
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may be functioning as a bifunctional transcriptional regulator activating or repressing transcription in response to ligand binding |
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acting as a histone methyltransferase |
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involved in the regulation of gene expression through stimulating the transition of RNA polymerase II from an initiation to fully elongation-competent state |
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SET-domain histone methyltransferase that primarily di-methylates nucleosomal histone H3 lysine 36 (H3K36), through an autoregulatory mechanism |
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autoregulatory mechanism of NSD1, providing insight into the molecular mechanism of the nucleosomal substrate selectivity of this disease-related H3K36 methyltransferase |
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critical in maintaining the chromatin integrity |
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NSD1, NSD2 and NSD3, have crucial roles in chromatin regulation and are implicated in oncogenesis |