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FLASH GENE
Symbol NRTN contributors: - updated : 29-10-2005
HGNC name neurturin
HGNC id 8007
Location 19p13.3      Physical location : 5.823.817 - 5.828.334
Synonym symbol(s) NTN
DNA
TYPE functioning gene
STRUCTURE 4.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
PTPRS 19p13.3 protein tyrosine phosphatase, receptor type, S LOC388496 19 LOC388496 LOC148066 19p13.3 zinc and ring finger 4 PLAC2 19p13.3 placenta-specific 2 LOC148064 19p13.3 similar to small nuclear ribonucleoprotein E SAFB2 19p13.3 scaffold attachment factor B2 SAFB 19p13.3-p13.2 scaffold attachment factor B LOC125988 19p13.3 hypothetical gene LOC125988 SCDR10 19p13.3 short-chain dehydrogenase/reductase 10 RPL36 19p13.3-p13.2 ribosomal protein L36 PRSS15 19p13.2 protease, serine, 15 MGC39581 19p13.3 hypothetical protein MGC39581 MGC24975 19p13.3 hypothetical protein MGC24975 LOC56931 19p13.3 hypothetical protein from EUROIMAGE 1967720 FUT6 19p13.3 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) NRTN 19p13.3 neurturin FUT3 19p13.3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group included) FUT5 19p13.3 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) NDUFA11 19p13.3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa CAPS 19p13.3 calcyphosine RANBP3 19p13.3 RAN binding protein 3 RFX2 19p13.3 regulatory factor X, 2 (influences HLA class II expression) BGR 19p13.3 bubblegum related protein LOC388497 19 LOC388497 MLLT1 19p13.3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 ASAH3 19p13.3 N-acylsphingosine amidohydrolase (alkaline ceramidase) 3 CLPP 19p13.2 ClpP caseinolytic protease, ATP-dependent, proteolytic subunit homolog (E. coli) SPATA11 19p13.3 spermatogenesis associated 11 PSPN 19p13.3 persephin GTF2F1 19p13.3 general transcription factor IIF, polypeptide 1, 74kDa LOC390877 19 similar to adenylate kinase (EC 2.7.4.3), cytosolic - common carp KHSRP 19p13.3 KH-type splicing regulatory protein (FUSE binding protein 2) MGC34725 19p13.3 hypothetical protein MGC34725 MGC2615 19p13.3 hypothetical protein MGC2615
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Nervousnervecranial nerve   
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
intraspecies homolog to glial cell line derived neurotrophic factor
Homologene
FAMILY TGFB superfamily, GDNF subfamily
CATEGORY signaling growth factor
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • may regulate the development and maintenance of the central nervous system
  • involved in processes subserving both the organization of the cortical region during development and the functional activity and maintenance of the mature hippocampal neurons
  • may regulate the development and maintenance of the CNS
  • might control the size of non-neuronal cell population such as haemopoietic cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component homodimer, disulfide-linked
    INTERACTION
    DNA
    RNA
    small molecule
    protein RET ligand, through GFRA2 and/or GFRA1
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in Hirschsprung disease
    Susceptibility contributor to susceptibility to Hirschsprung disease
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS