Selected-GenAtlas references SOURCE GeneCards NCBI Gene Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NRROS contributors: mct - updated : 25-08-2020
HGNC name negative regulator of reactive oxygen species
HGNC id 24613
Corresponding disease
SENEBAC seizures, early-onset, with neurodegeneration and brain calcification
Location 3q29      Physical location : -
Synonym name
  • leucine rich repeat containing 33
  • leucine rich repeat containing 33similar to RIKEN cDNA E430025L02 gene
  • Synonym symbol(s) GARPL1, MGC50789, UNQ3030, ELLP3030, LRRC33, SENEBAC, MGC50789
    DNA
    TYPE functioning gene
    STRUCTURE 22.31 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2556 - 692 - 2019 31600200
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   highly Homo sapiens
     liver   highly Homo sapiens
    Lymphoid/Immunespleen   highly Homo sapiens
     thymus   highly Homo sapiens
    Respiratorylung   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly Homo sapiens
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousglia Homo sapiens
    not specificmacrophage Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 17 putative LRRs in the extracellular region but lacking a cytoplasmic Toll/IL-1 receptor (TIR) domain
  • HOMOLOGY
    interspecies homolog to murine Lrrc33
    Homologene
    FAMILY LRR family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text localize on the endoplasmic reticulum (ER) and cell surface
    basic FUNCTION
  • plays a critical role in desensitizing TLR signaling
  • NRROS and TLRs may form a negative-feedback loop, which is important for the maintenance of immune homeostasis
  • limits ROS generation by phagocytes during inflammatory responses
  • NRROS negatively regulates the differentiation of osteoclasts, but not osteoblasts
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    NRROS-mediated pathway that controls CNS-resident macrophage development and affects neurological function
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NRROS is localized to the endoplasmic reticulum, where it directly interacts with nascent CYBB
  • NRROS is a novel negative regulator of TNFSF11-induced osteoclastogenesis
  • is required for normal expression of SALL1 and other microglial genes that are important for microglial development and function
  • is a novel binding and potential regulating protein of TGFB1 function in human acute myeloid leukemia cells
  • LRRC32 and NRROS, bind and anchor latent TGFB1 to the cell surface for TGFB1 activation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SENEBAC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Nrros knockout mice develop paraparesis with demyelination, with noted loss of microglia and axons
  • mice deficient in Nrros, a myeloid-expressed transmembrane protein in the endoplasmic reticulum, develop spontaneous neurological disorders