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FLASH GENE
Symbol NRK contributors: mct - updated : 28-06-2012
HGNC name Nik related kinase
HGNC id 25391
Location Xq22.3      Physical location : 105.066.535 - 105.202.596
Synonym name
  • Nik-like embryo-specific kinase
    • Synonym symbol(s) NESK
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 136.07 kb     29 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    29 - 8080 - 1582 - 2003 12837278
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly
    Reproductivefemale systemovary  moderately
     female systemplacenta  highly
    Urinarykidney   highly
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Muscularstriatumskeletal   Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text
  • placenta
  • specifically expressed in the spongiotrophoblast layer, a fetus-derived region of the placenta
  • in the fetal skeletal muscle
    • IMPRINTING paternally
    text
  • paternally derived NRK is preferentially but incompletely inactivated in placenta
    • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Nrk
    Homologene
    FAMILY
  • Ser/Thr protein kinase family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • acting as an activator of the JNK pathway
  • may be involved in the regulation of actin cytoskeletal organization in skeletal muscle cells through cofilin phosphorylation
  • required for placental development
  • does not regulate the levels of progesterone and estrogen
  • NRK-mediated signaling may potentially operate in labor
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • cofilin is likely to be a direct substrate of NRK
  • NRK and ESX1 may participate in the same signaling pathway that regulates placental development
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    reproductionpregnancy 
    serves as a potential target to therapeutically control human labor
    ANIMAL & CELL MODELS
  • Pregnant mice exhibited a severe defect in labor when all the fetuses and placentas were Nrk-null in utero