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FLASH GENE
Symbol NRIP3 contributors: mct/npt - updated : 13-04-2010
HGNC name nuclear receptor interacting protein 3
HGNC id 1167
Location 11p15.4      Physical location : 9.002.122 - 9.025.596
Synonym name
  • chromosome 11 open reading frame 14
  • sarcoma antigen NY-SAR-105
  • Synonym symbol(s) C11orf14, NY-SAR-105
    DNA
    TYPE functioning gene
    STRUCTURE 21.16 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3809 - 241 - Balgobind (2009)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivefemale systemuterus   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to Drosophila CG2789
    homolog to murine Nrip3
    Homologene
    FAMILY
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • it is one of the genes to be frequently hypermethylated in non-small cell lung cancer, hence it may potentially play a role in the pathogenesis of other cancers (Balgobind 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    to MLL (5prime MLL intron 9 was fused to NRIP3 intron 1) in pediatric acute myeloid leukemia (Balgobind 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS