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FLASH GENE
Symbol NRIP1 contributors: mct - updated : 09-05-2017
HGNC name nuclear receptor interacting protein 1
HGNC id 8001
Location 21q11.2      Physical location : 16.333.555 - 16.437.126
Synonym name
  • receptor interacting protein 140
  • nuclear factor RIP140
  • Synonym symbol(s) RIP140, FLJ77253
    DNA
    TYPE functioning gene
    STRUCTURE 103.57 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC391264 21 similar to Sorting nexin 19 ANKRD21 21q11.2 ankyrin repeat domain 21 LOC391265 21 similar to cDNA sequence BC021523 LOC388810 21 hypothetical gene supported by AL834140 LOC343720 21q11.2 similar to fem-1 homolog a (C.elegans) TERF1P 21 telomeric repeat binding factor (NIMA-interacting) 1 pseudogene LOC391266 21 similar to h2-calponin CYP4F3LP 21p11 cytochrome P450, family 4, subfamily F, polypeptide 3-like pseudogene LOC391267 21 similar to SNAG1 LOC388812 21 similar to Ankyrin repeat domain protein 18A C21orf81 21q22.1 chromosome 21 open reading frame 81 LOC391268 21 similar to KIAA0685 protein LOC391269 21 similar to hypothetical protein DKFZp434A171 LOC375108 21q11.2 membrane-associated phospholipase A1 beta RBM11 21q11 RNA binding motif protein 11 ABCC13 21q11.1 ATP-binding cassette, sub-family C (CFTR/MRP), member 13 STCH 21q11.2 stress 70 protein chaperone, microsome-associated, 60kDa SAMSN1 21q11 SAM domain, SH3 domain and nuclear localisation signals, 1 LOC388813 21 LOC388813 POLR2CP 21q11.2 polymerase (RNA) II (DNA directed) polypeptide C, pseudogene NRIP1 21q11.2 nuclear receptor interacting protein 1 LOC388814 21 LOC388814 HCP42 21q11.2 cytochrome c, somatic pseudogene USP25 21q11.2 ubiquitin specific protease 25 VDAC2P 21q11.2 voltage-dependent anion channel 2 pseudogene LOC388815 21 hypothetical gene supported by AF486622
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 7556 - 1158 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systembreastmammary gland highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • central domain, serine/threonine rich
  • basic and acid domains
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • modulating transcriptional activation by the estrogen receptor, essential for female fertility (in mice) and potential coactivator of hormone-regulated gene
  • transcription
  • acting as a potent corepressor of transcription from the SF-1 responsive cAMP regulatory sequence 2 (CRS2) element of the CYP17 gene and a variety of SF-1 responsive promoter genes
  • atypical transcription inhibitor playing, by repressing nuclear hormone receptor activity, a fundamental role
  • via its interplay with other coregulators, plays a fundamental role in determining both the normal and pathogenic physiological state
  • having a a role as an activator of specific networks of genes in the liver
  • playing a fundamental role in mitochondrial activity
  • modulating transcriptional activity of the estrogen receptor
  • functional role in chromatin remodeling to repress hormone target gene expression (Park 2009)
  • transcriptional coregulator NRIP1 regulates intestinal homeostasis and tumorigenesis
  • inhibited intestinal epithelial cell proliferation and apoptosis
  • tumor suppressor role for NRIP1 in colon cancer
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • found in a complex with both NR3C1 and YWHAH
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with several nuclear receptors
  • interacts with the hormone-dependent activation domain AF2 of nuclear receptors
  • interacting with NR2C1, RARA and RXRB homodimers, RARA/RXRB heterodimers
  • interacting with HDAC1, HDAC2, HDAC3, CTBP1, CTBP2, ESR1, HDAC5, HDAC6, NR3C1, NR3C2, YWHAH, JUN and FOS
  • in cancer cells, NRIP1 stimulated APC transcription and inhibited CTNNB1 activation and target gene expression
  • cell & other
    REGULATION
    Other regulated by estrogens and retinoic acid
    acetylation regulates its nuclear translocation and corepressive activity
    phosphorylation enhances interaction with YWHAH
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target attractive target to sensitize tumor cells to retinoid-based differentiation therapy
    ANIMAL & CELL MODELS
  • mice lacking Rip140 exhibited improved regenerative capacity in the intestine, while mice overexpressing Rip140 displayed reduced recovery