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FLASH GENE
Symbol NRIP1 contributors: mct - updated : 09-05-2017
HGNC name nuclear receptor interacting protein 1
HGNC id 8001
Location 21q11.2      Physical location : 16.333.555 - 16.437.126
Synonym name
  • receptor interacting protein 140
  • nuclear factor RIP140
  • Synonym symbol(s) RIP140, FLJ77253
    DNA
    TYPE functioning gene
    STRUCTURE 103.57 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 7556 - 1158 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systembreastmammary gland highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • central domain, serine/threonine rich
  • basic and acid domains
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • modulating transcriptional activation by the estrogen receptor, essential for female fertility (in mice) and potential coactivator of hormone-regulated gene
  • transcription
  • acting as a potent corepressor of transcription from the SF-1 responsive cAMP regulatory sequence 2 (CRS2) element of the CYP17 gene and a variety of SF-1 responsive promoter genes
  • atypical transcription inhibitor playing, by repressing nuclear hormone receptor activity, a fundamental role
  • via its interplay with other coregulators, plays a fundamental role in determining both the normal and pathogenic physiological state
  • having a a role as an activator of specific networks of genes in the liver
  • playing a fundamental role in mitochondrial activity
  • modulating transcriptional activity of the estrogen receptor
  • functional role in chromatin remodeling to repress hormone target gene expression (Park 2009)
  • transcriptional coregulator NRIP1 regulates intestinal homeostasis and tumorigenesis
  • inhibited intestinal epithelial cell proliferation and apoptosis
  • tumor suppressor role for NRIP1 in colon cancer
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • found in a complex with both NR3C1 and YWHAH
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with several nuclear receptors
  • interacts with the hormone-dependent activation domain AF2 of nuclear receptors
  • interacting with NR2C1, RARA and RXRB homodimers, RARA/RXRB heterodimers
  • interacting with HDAC1, HDAC2, HDAC3, CTBP1, CTBP2, ESR1, HDAC5, HDAC6, NR3C1, NR3C2, YWHAH, JUN and FOS
  • in cancer cells, NRIP1 stimulated APC transcription and inhibited CTNNB1 activation and target gene expression
  • cell & other
    REGULATION
    Other regulated by estrogens and retinoic acid
    acetylation regulates its nuclear translocation and corepressive activity
    phosphorylation enhances interaction with YWHAH
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target attractive target to sensitize tumor cells to retinoid-based differentiation therapy
    ANIMAL & CELL MODELS
  • mice lacking Rip140 exhibited improved regenerative capacity in the intestine, while mice overexpressing Rip140 displayed reduced recovery