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FLASH GENE

Symbol

NRG2

contributors: - updated : 22-02-2006

HGNC name	neuregulin 2
HGNC id	7998

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	DEL5Q31.3 chromosome 5q31.3 microdeletion
Location	5q23-q33      Physical location : 139.226.363 - 139.422.884
Synonym name	neural and thymus derived activator for the ErbB kinase
Synonym symbol(s)	NTAK, DON1

DNA

TYPE	functioning gene
STRUCTURE	55.00 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Binding site   transcription factor
text structure	TFIIIA, SP1, AP2, YY1 transcription factors binding sites and a GC box sequence instead of a TATA box

MAPPING

cloned

Y

linked

N

status

provisional

Map

see CMT4C

RNA

TRANSCRIPTS	type	messenger

text	with several alternatively spliced variants, alpha and beta forms (Ring)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NRG2-I1 - splicing 3020 - 850 - Carraway lacks exons 6, 7 NRG2-I2 - splicing 3002 - 844 brain, heart Carraway lacks exons 5, 7 NRG2-I3 - splicing 3044 - 858 hippocampus, cerebellum, spinal cord Carraway excludes exon 6 NRG2-I4 - splicing 3026 - 852 olfactory bulb Carraway excludes exon 5 NRG2-I5 - splicing 1576 - 426 liver only Carraway excludes exons 7, 9-12 NRG2-I6 - splicing 1497 - 422 liver only Carraway excludes exons 8-12 NTAK alpha - - - - - in all tissues including the brain Nakano having complete EGF-like domain motifs, which have consensus sequences containing three disulfide bonds induce phosphorylation in ERBB3, transactivate ERBB2,stimulate the growth of endothelial cells, because endothelial cells have ERBB2, ERBB3, and ERBB4 and stimulate growth of breast cancer cells NTAK beta - - - - - restricted to the brain Nakano have complete EGF-like domain motifs, which have consensus sequences containing three disulfide bonds induce phosphorylation in ERBB4, transactivate ERBB2, stimulate the growth of endothelial cells, because endothelial cells have ERBB2, ERBB3, and ERBB4 and stimulate growth of breast cancer cells NTAK gamma - - - - - - Nakano an incomplete EGF-like domain, which does not have the third cysteine loop inhibiting angiogenesis NTAK delta - - - - - expressed in neuroblastoma cell line Nakano same N-terminal part, including the Ig-like domain, as the other isoforms but is missing the EGF-like domain causing G1 arrest in vascular endothelial cells and inhibiting angiogenesis

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Respiratory lung

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Nervous Schwann cell

cell lineage
cell lines	neuroblastoma
fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	developing heart

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an immunoglobulin domain
	an EGF-like domain
	a ser/thr rich domain
	a transmembrane region (lacking in isoforms 5 and 6)

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to rattus LOC291668
	homolog to murine LOC381149

Homologene

FAMILY

epidermal growth factor (EGF) family

CATEGORY

regulatory , receptor membrane ligand ion channel

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
text	membrane-bound or soluble form

basic FUNCTION	involved in growth and differentiation of epithelial, neuronal, glial and other cell types
	ligand of Erb3/Erb4 receptor tyrosine kinase
	recruits ERBB1 and ERBB2 and may promote the heterodimerization with the EGF receptor
	promotes cell death of prostate cancer cells
	may be a signal that regulates synaptic differentiation

CELLULAR PROCESS	cell life, differentiation
	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

binding directly to ERBB3 and ERBB4 and transactivating ERBB2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DEL5Q31.3

Susceptibility

Variant & Polymorphism

Candidate gene	candidate agents for suppression of tumor growth and metastasis
Marker
Therapy target

ANIMAL & CELL MODELS