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FLASH GENE
Symbol NRDE2 contributors: mct - updated : 10-11-2021
HGNC name NRDE-2, necessary for RNA interference, domain containing
HGNC id 20186
Location 14q32.11      Physical location : -
Genatlas name nuclear RNAi-defective 2
Synonym name
  • hypothetical protein LOC55051
  • chromosome 14 open reading frame 102
  • UPF0614 protein C14orf102
  • Synonym symbol(s) FLJ10008, FLJ14051, C14orf102
    DNA
    TYPE functioning gene
    STRUCTURE 64.11 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3824 132.5 1164 - 2019 30842217
    - - 3480 106.7 933 - 2019 30842217
    14 - 14008 - 1164 - 2019 30842217
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • mainly localizes in nuclear speckles, where it inhibits MTREX recruitment and RNA degradation, and thereby ensures efficient mRNA nuclear export
  • basic FUNCTION
  • is a component of the nuclear RNAi machinery
  • NRDE2 and MTREX play a role in the DNA damage response by maintaining low DNA double-strand break levels
  • is an essential protein required for suppressing intron retention in a subset of pre-mRNAs containing short, GC-rich introns with relatively weak 5' and 3' splice sites
  • conserved role for NRDE2 in RNA splicing, which characterizes the severe genomic instability phenotypes observed upon loss of NRDE2
  • NRDE2 is a nuclear exosome negative regulator that ensures mRNA stability and nuclear export
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MTREX association with NRDE2, defines a novel function for MTREX in the DNA damage response pathway
  • NRDE2 preferentially interacts with components of the U5 small nuclear ribonucleoprotein (snRNP), the exon junction complex, and the RNA exosome
  • NRDE2 specifically binds to and promotes the efficient splicing of CEP131 pre-mRNA, and depleting NRDE2 dramatically reduces CEP131 protein expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS