basic FUNCTION
| is a component of the nuclear RNAi machinery |
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NRDE2 and MTREX play a role in the DNA damage response by maintaining low DNA double-strand break levels |
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is an essential protein required for suppressing intron retention in a subset of pre-mRNAs containing short, GC-rich introns with relatively weak 5' and 3' splice sites |
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conserved role for NRDE2 in RNA splicing, which characterizes the severe genomic instability phenotypes observed upon loss of NRDE2 |
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NRDE2 is a nuclear exosome negative regulator that ensures mRNA stability and nuclear export |